Publications by authors named "Genyang Xin"
Article Synopsis
- Current metagenomic tools struggle to identify highly divergent RNA viruses, prompting the development of a deep learning algorithm called LucaProt to improve detection in diverse ecosystems.
- LucaProt combines sequence and structural data to identify a significant number of RNA virus sequences, uncovering 161,979 potential species and 180 supergroups, including some with long and complex genomes.
- The study not only confirmed some of these novel RNA viruses but also demonstrated their presence across various environments, showcasing the vast diversity of RNA viruses and enhancing our understanding and documentation of the global RNA virome.
Article Synopsis
- The Seoul orthohantavirus (SEOV) is a major cause of hemorrhagic fever with renal syndrome (HFRS) in China, primarily found in small mammal populations across the country, particularly in Yunnan province.
- A study involving 1,784 small mammals identified 37 SEOV-positive rats, indicating a connection between rodent populations and HFRS outbreaks, while also identifying three SEOV variants, including two novel ones.
- Phylogenetic analysis suggests SEOV originated in the Yunnan-Kweichow Plateau and has since spread globally through rodents, highlighting the need for further research due to the virus's expanding presence and genetic diversity.
Unlabelled: Companion animals such as cats and dogs harbor diverse microbial communities that can potentially impact human health due to close and frequent contact. To better characterize their total infectomes and assess zoonotic risks, we characterized the overall infectomes of companion animals (cats and dogs) and evaluated their potential zoonotic risks. Meta-transcriptomic analyses were performed on 239 samples from cats and dogs collected across China, identifying 24 viral species, 270 bacterial genera, and two fungal genera.
View Article and Find Full Text PDFMosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a meta-transcriptomic approach, we determined the viromes of 2,438 individual mosquitoes (81 species), spanning ~4,000 km along latitudes and longitudes in China.
View Article and Find Full Text PDFSince 2018, the outbreaks of genotype II African swine fever virus (ASFV) in China and several eastern Asian countries have caused a huge impact on the local swine industry, resulting in huge economic losses. However, little is known about the origin, genomic diversity, evolutionary features, and epidemiological history of the genotype II ASFV. Here, 14 high-quality complete genomes of ASFVs were generated via sequencing of samples collected from China over the course of 3 years, followed by phylogenetic and phylodynamic analyses.
View Article and Find Full Text PDFMosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Using a meta-transcriptomic approach, we analysed the virome of 2,438 individual mosquitos (79 species), spanning ~4000 km along latitudes and longitudes in China.
View Article and Find Full Text PDFArticle Synopsis
- Bats are hosts to various zoonotic viruses, but little is known about virus diversity and co-infection rates within individual bats, particularly studied in Yunnan, China.* -
- An analysis of 149 bats revealed high levels of virus co-infection and spillover, suggesting that these interactions may enhance virus evolution and emergence.* -
- The study identified five viral species likely pathogenic to humans or livestock, including a novel recombinant SARS-like coronavirus that poses a significant risk due to its ability to bind the human ACE2 receptor.*
Cats harbor many important viral pathogens, and the knowledge of their diversity has been greatly expanded thanks to increasingly popular molecular sequencing techniques. While the diversity is mostly described in numerous regionally defined studies, there lacks a global overview of the diversity for the majority of cat viruses, and therefore our understanding of the evolution and epidemiology of these viruses was generally inadequate. In this study, we analyzed 12,377 genetic sequences from 25 cat virus species and conducted comprehensive phylodynamic analyses.
View Article and Find Full Text PDFBats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within bats at the level of individual animals, and hence the frequency of virus co-infection and inter-species transmission. Using an unbiased meta-transcriptomics approach we characterised the mammalian associated viruses present in 149 individual bats sampled from Yunnan province, China.
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