Insights from a Wolfram syndrome cohort: clinical and molecular findings from a specialized diabetes reference center.

Objective: Considering the rarity and clinical and molecular diversity of Wolfram syndrome (WS), the objective of this study was to identify patients with a clinical presentation suggestive of WS following up at a single Brazilian diabetes service and analyze their clinical and molecular characteristics.

Subjects And Methods: The study included all patients with a clinical presentation of WS following up between 1991 and 2022 with early-onset diabetes mellitus and other WS signs and symptoms. A retrospective analysis was conducted, including patients' age, sex, consanguinity, age at symptom onset, diagnosis of diabetes mellitus, optic atrophy, diabetes insipidus, neurological and psychiatric disorders, hearing loss, urinary disorders, hypogonadism, and molecular analysis.

Intraocular pressure, ultrasonographic and echobiometric findings of juvenile Yacare caiman (Caiman yacare) eye.

Objective: The aim was to determine the intraocular pressure (IOP), the ultrasonographic and echobiometric findings in the eyes of juvenile Yacare caiman (Caiman yacare).

Animals: Twenty-two healthy caimans from a breeding farm in Brazilian Pantanal.

Procedures: Intraocular pressure was measured under physical restraint and topical anesthesia by applanation tonometry.

Toxoplasma gondii: a morphometric analysis of the wall and epithelial cells of pigs intestine.

The aim of this study was to perform a morphometric analysis of the different layers of the jejunal wall and epithelial cells of pigs with toxoplasmosis. Experiments were conducted using 10, 88-day-old crossbred (Pietran x Wessex) pigs divided into two groups: control (n=5) and experimental (n=5). The experimental group consisted of animals inoculated orally with 5000 sporulated oocysts of a genotype III strain of Toxoplasma gondii.

Quantitative and morphometric changes of subpopulations of myenteric neurons in swines with toxoplasmosis.

The consequences of the infection caused by Toxoplasma gondii in myenteric neurons of the jejunum of swines reactive to NADH-diaphorase and NADPH-diaphorase were evaluated in this study. Ten 88-day-old mixed-breed swines (Pietrain and Wessex) were assigned into two groups: Control (n=5) and Experimental (n=5), which orally received 5000 sporulated oocysts from a genotype III T. gondii strain.