A Newly Discovered Epidemic Area of Echinococcus multilocularis in West Gansu Province in China.

Alveolar echinococcosis (AE) is a lethal parasitic disease. In Gansu Province of China, all AE cases reported in literature were from Zhang and Min Counties, the southern part of the province. Here, we report the discovery of nine AE cases and one cystic echinococcosis (CE) case from Nanfeng Town of Minle County, in the middle of Hexi Corridor in west Gansu Province.

Incidence of Japanese encephalitis, visceral leishmaniasis and malaria before and after the Wenchuan earthquake, in China.

The objective of this study was to investigate the incidence of insect-borne diseases from 2005 to 2011, before and after the 2008 Wenchuan earthquake in Longnan City, Gansu Province, China. The data include Japanese encephalitis, Kala-azar and malaria cases from 2005 to 2011 that occurred in Longnan City. We calculated the incidence rates and analyzed the epidemiological characteristics of the diseases before and after the Wenchuan earthquake.

[Experimental treatment on alveolar hydatid disease in mice with multi-frequency focused ultrasound].

Objective: To investigate the efficacy of multi-frequency focused ultrasound (MfFU) in the treatment of alveolar hydatid disease in mice.

Methods: Thirty Kunming mice infected subcutaneously with alveolar protoscoleces were divided into 3 groups randomly of 10 mice each and irradiated with different intensity of MfFU. Mice in the experiment groups B and C were irradiated only once for 5 min and group A served as control.

[In vitro influence of multi-frequency focused ultrasound on the ultrastructure of Echinococcus granulosus hydatid cysts].

Objective: To investigate the change of Echinococcus granulosus hydatid cysts in vitro treated with single-frequency and multi-frequency focused ultrasound.

Methods: Mice were inoculated with echinococcus protoscolices from infected sheep, and sacrificed after one year. Forty cysts (about 2 cm in diameter) were taken from infected mice, and randomly divided into four groups.

[In vitro observation on albendazole sulfoxide and its enantiomers against Echinococcus granulosus protoscolex].

Objective: To investigate in vitro anti-hydatid efficacy on Echinococcus granulosus protoscolex (EgPSC) by using albendazole sulfoxide (ASOX) and its two enantiomeric antipodes, L-ASOX and D-ASOX.

Methods: Eg protoscoleces were divided into eight groups and cultured in the DMEM culture media under two concentrations(50 microg/ml and 100 microg/ml) of ASOX, L-ASOX and D-ASOX respectively. The appropriate controls included (i) a culture containing an equal amount of DMSO and (ii) a culture medium alone.

[Effect of combined pentoxifylline and albendazole against echinococcus multilocularis infection in mice].

Objective: To observe the effect of pentoxifylline (PTX), albendazole (ABZ), and a combination of PTX and ABZ in mice infected with Echinococcus multilocularis (E.M).

Methods: The first part of the experiment was to observe the in vitro effect of PTX on the cultured E.