Liver toxicity after switching or simplifying to nevirapine-based therapy is not related to CD4 cell counts: results of the TOSCANA study.

Purpose: The TOSCANA study aimed to determine the relationship between CD4 cell counts and liver toxicity in patients undergoing treatment simplification or substitution with nevirapine due to the toxicity or poor tolerability of a previous regimen.

Methods: A retrospective analysis was conducted of patients with prior viral suppression who were switched to nevirapine.

Results: Overall, 221 patients were included, representing 1134.