Clinical Manifestations.

Background: This study focused on comparing clinical and neuropsychological aspects in individuals with subjective cognitive decline (SCD) versus healthy controls (HCs) in a memory clinic, aiming to identify factors linked to the progression towards mild cognitive impairment (MCI) or dementia.

Method: We retrospectively analysed data from 945 SCD patients and 68 HCs at Clínica Universidad de Navarra memory clinic between 2001 and 2017, with 450 followed up until January 2020, the study involved various assessments including medical interviews, lab tests, neuropsychological evaluations (during the first interview and follow-ups), and brain imaging. All the neuropsychological variables were adjusted for age, sex and education.

Clusters of cognitive performance predict long-term cognitive impairment in elderly patients with subjective memory complaints and healthy controls.

Introduction: Patients with subjective memory complaints (SMC) may include subgroups with different neuropsychological profiles and risks of cognitive impairment.

Methods: Cluster analysis was performed on two datasets (n: 630 and 734) comprising demographic and neuropsychological data from SMC and healthy controls (HC). Survival analyses were conducted on clusters.

Structural neuroimaging changes associated with subjective cognitive decline from a clinical sample.

Background: Alzheimer's disease (AD) is characterized by progressive deterioration of cognitive functions. Some individuals with subjective cognitive decline (SCD) are in the early phase of the disease and subsequently progress through the AD continuum. Although neuroimaging biomarkers could be used for the accurate and early diagnosis of preclinical AD, the findings in SCD samples have been heterogeneous.

A Neuropsychological Rehabilitation Program for Cognitive Impairment in Psychiatric and Neurological Conditions: A Review That Supports Its Efficacy.

Neuropsychological rehabilitation has been the focus of much scientific research over the past decades due to its efficacy in different pathologies. Advances in the neuropsychology field have led to improvements and changes in neuropsychological interventions, which in turn have given rise to different approaches and rehabilitation programs. REHACOP is an integrative neuropsychological rehabilitation program designed by specialist neuropsychologists.

Effects of Cognitive Rehabilitation on Cognition, Apathy, Quality of Life, and Subjective Complaints in the Elderly: A Randomized Controlled Trial.

Objective: To determine the efficacy of a new-generation integrative cognitive rehabilitation (CR) program (Rehacop) on cognition, clinical symptoms, quality of life (QoL), and subjective complaints in the elderly.

Design: A randomized controlled trial study with a cohort of elderly people over 55 years of age.

Setting: Communities of the Basque Country (Spain).

The impact of apathy on cognitive performance in the elderly.

Objectives: To examine the impact of apathy on cognitive performance in the elderly following the conceptual principles proposed by Marin and Stuss et al and to determine the role of the symptoms of apathy in different cognitive domains.

Methods: Cross-sectional study with a cohort of healthy elderly subjects over 55 years old (n = 140). One hundred forty healthy-elderly subjects (aged 79.

RNAseq based transcriptomics study of SMCs from carotid atherosclerotic plaque: BMP2 and IDs proteins are crucial regulators of plaque stability.

Carotid artery atherosclerosis is a risk factor to develop cerebrovascular disease. Atheroma plaque can become instable and provoke a cerebrovascular event or else remain stable as asymptomatic type. The exact mechanism involved in plaque destabilization is not known but includes among other events smooth muscle cell (SMC) differentiation.