Primary Chemoablation of Recurrent Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer With UGN-102: A Single-Arm, Open-Label, Phase 3 Trial (ENVISION).

Purpose: We evaluate the efficacy and safety of UGN-102 chemoablation for the primary treatment of patients with recurrent low-grade intermediate-risk nonmuscle-invasive bladder cancer.

Materials And Methods: ENVISION is an ongoing, multinational, single-arm, phase 3 study in patients with a biopsy-proven recurrence of untreated low-grade intermediate-risk nonmuscle-invasive bladder cancer. Patients received 6 weekly intravesical instillations of UGN-102 (mitomycin; outpatient setting) and were evaluated at 3 months.

Treatment of Low-grade Intermediate-risk Nonmuscle-invasive Bladder Cancer With UGN-102 ± Transurethral Resection of Bladder Tumor Compared to Transurethral Resection of Bladder Tumor Monotherapy: A Randomized, Controlled, Phase 3 Trial (ATLAS).

Purpose: Low-grade intermediate-risk nonmuscle-invasive bladder cancer is a chronic illness commonly treated by repetitive transurethral resection of bladder tumor. We compared the efficacy and safety of intravesical chemoablation with UGN-102 (a reverse thermal gel containing mitomycin), with or without subsequent transurethral resection of bladder tumor, to transurethral resection of bladder tumor alone in patients with low-grade intermediate-risk nonmuscle-invasive bladder cancer.

Materials And Methods: This prospective, randomized, phase 3 trial recruited patients with new or recurrent low-grade intermediate-risk nonmuscle-invasive bladder cancer to receive initial treatment with either UGN-102 once weekly for 6 weeks or transurethral resection of bladder tumor.

Subcutaneous nephrovesical bypass in a patient with advanced prostate cancer.

In the presence of hydronephrosis, as a result of ureteral malignant invasion, advanced pelvic tumor or retroperitoneal fibrosis, we most often perform a double J stent or percutaneous nephrostomy. In the search for a better quality of life for our patients in recent years in urological practice is increasingly becoming the use of subcutaneous nephrovesical bypass due to its proven safety, effectiveness and minimal invasiveness.

Early result of meshed split-tickness skin graft in patient with paraffinoma of penis.

We present you an early result of 38 year old man, who was operated in 2020 using meshed split-tickness skin graft (mSTSG) for paraffinoma localized to the penis and pubic area. Here we present picture of pre - and postoperativ view of the penis and describe the surgical procedure.

Unmeshed split-thickness SKIN grafts for penile plastic in patients with paraffinoma.

Paraffinoma of male genitalia (PMG) is a chronic granulomatous reaction to a "foreign body" developed after injection of exogenous substances (ES). There are many plastic surgical techniques for aesthetic and functional recovery of affected tissues. We report here use of unmeshed split-thickness skin grafts (unmSTSG) in patients with genital paraffinoma.

Successful in vitro fertilization in a 30 years old man with bilateral abdominal cryptorchidism.

Retention of the testis is one of the most common congenital malformation in male infants. The incidence of this disease is 1-2% at 1 year of age. As nonpalpable are reported around 20% of cases and in up to 30% of neonates may affect both sides.

A rare case of huge villous adenoma of the renal pelvis deforming the abdominal wall.

The villous adenoma is a benign epithelial tumor affecting most often the gastrointestinal tract, especially the colon and rectum. The incidence of this disease in the genitourinary tract is less than 1% as the most commonly affected organs are bladder, urethra, prostate, vulva and vagina. Only several cases of villous adenoma in the renal pelvis have been reported in the scientific literature.

Low-intensity extracorporeal shockwave therapy in the treatment of erectile dysfunction after penile trauma.

In urology low-intensity extracorporeal shockwave therapy (LI-ESWT) finds major application in the treatment of erectile dysfunction (ED) after nerve-sparing radical retropubic prostatectomy and Peyronie's disease. We presented a rare case of application of LI-ESWT in a 39-years old man with erectile dysfunction after penile trauma obtained during sexual intercourse.

Torsion of the testis with perineal ectopy.

Congenital testicular anomalies affect about 5% of newborn boys. Testicular torsion is a rare anomaly that occurs in 1 in 4000 men under the age of 25. Perineal ectopia is an even more rare anomaly.

A rare case of iatrogenic vesicovaginal fistula arising from a forgotten gauze strip during Caesarean section.

The incidence of iatrogenic vesicovaginal fistulas in women after gynecological surgery is 82%, as hysterectomy being the most common cause for them - 88%. We presented a rare case of iatrogenic vesicovaginal fistula resulting from a series of errors and forgotten gauze strip in a 26-years-old woman after a third Caesarean section.