Publications by authors named "Genoah Collins"
Myeloperoxidase (MPO) is released by neutrophils in inflamed tissues. MPO oxidizes chloride, bromide, and thiocyanate to produce hypochlorous acid (HOCl), hypobromous acid (HOBr), and hypothiocyanous acid (HOSCN), respectively. These oxidants are toxic to pathogens, but may also react with host cells to elicit biological activity and potential toxicity.
View Article and Find Full Text PDFPrediabetes affects 1 in 3 American adults and is characterized by insulin resistance, insulin hypersecretion, and impaired glucose tolerance. Weanling LEW.1WR1 (1WR1) rats have increased blood insulin concentrations, so we hypothesized that young adult 1WR1 rats would develop impaired glucose tolerance due to the poor regulation of insulin.
View Article and Find Full Text PDFArticle Synopsis
- The study highlights that Black/African American patients made up nearly 70% of COVID-19 deaths in certain areas, yet targeted research on them is limited.
- Using advanced single-cell analyses of immune responses from Black/AA patients, researchers found that a specific type of neutrophil plays a critical role in causing severe respiratory issues during COVID-19, even when viral loads are low.
- Key findings reveal that these neutrophils produce high levels of inflammatory proteins, contributing to a harmful immune response that can lead to acute respiratory distress syndrome (ARDS) in this vulnerable population.