Optical transfer diagnosis of pigmented lesions.

Background: Optical transfer diagnosis is a novel melanoma detection system that uses morphologic-physiologic mapping.

Objective: To further evaluate the potential of optical transfer diagnosis for distinguishing benign from malignant pigmented melanocytic neoplasms.

Methods And Materials: Ninety-four patients with pigmented lesions suggestive of melanoma were referred for optical transfer diagnosis.

Optical transfer diagnosis of pigmented lesions: a pilot study.

Objective: To evaluate the potential of a novel imaging technology, optical transfer diagnosis (OTD), for differentiation of benign from malignant pigmented melanocytic lesions.

Design: Patients with pigmented lesions suspicious for melanoma were referred for OTD. After scanning, lesions were biopsied for histopathologic examination, each by two separate dermatopathologists.

Changes in human skin after topical PDT with hexyl aminolevulinate.

Background: Photodynamic therapy (PDT) induces physiological changes in human skin, but details and kinetics are not known.

Methods: Changes in human skin induced by PDT with red light in the presence of topically applied cream with the hexyl aminolevulinate (HAL) were investigated in the skin of five healthy volunteers. In addition to testing the effects of HAL-PDT three control studies were performed on the volunteers: (A) the HAL containing cream was applied to the skin without light exposure; (B) the cream without HAL was applied to the skin; (C) the skin was exposed to light in the absence of the cream.