Influence of elemental composition on the stability of restorative structures in permanent teeth in children from different geographical areas of residence.

Objective: Aim: To evaluate the correlation between the mineral composition of the hard tissues of the teeth and the percentage of defects and loss of various restorative materials in permanent teeth in children living in the lowland and mountainous geographical zones of Transcarpathian region.

Patients And Methods: Materials and Methods: 1050 permanent teeth of different groups filled with different materials were studied. An ultra-microscopic examination by the method of raster electron microscopy was carried out and the mineral composition of the teeth was evaluated.

STRUCTURE OF THE KNEE ARTICULAR CARTILAGE AFTER THE FEMUR AND TIBIA EXTRA-ARTICULAR INJURY.

Objective: The aim: To study the microscopic, ultramicroscopic, and histomorphometric features of the knee articular cartilage in rats with an extra-articular injury of the femur and tibia.

Patients And Methods: Materials and methods: 60 white laboratory rats divided into three groups (I - control; II - animals with traumatic femur injury; III - animals with traumatic tibia injury) were used for the study. The light microscopy was performed by Olympus BH-2 microscope (Japan), transmission electron microscopy - by JEM-1230 microscope (Japan).

FEATURES OF SKIN WOUNDS HEALING UNDER CHRONIC HYPERGLYCEMIA AND IMPROVEMENT OF THEIR TREATMENT METHODS.

Objective: The aim: The work was aimed to study the histological, morphometric and planimetric features of skin regeneration in mature rats with chronic hyperglycemia under the influence of platelet-rich plasma.

Patients And Methods: Materials and methods: 60 mature white laboratory rats were used. The animals were divided into three groups (I - control with mechanical skin injuries; II - rats with chronic hyperglycemia and modeled mechanical skin injuries; III - animals with the chronic hyperglycemia and modeled mechanical skin injuries which were injected with the platelet-rich plasma).

Morphological Characteristics and Correction of Long Tubular Bone Regeneration under Chronic Hyperglycemia Influence.

Introduction: Unsatisfactory consequences of bone regeneration disorders in diabetes mellitus (DM) patients, their high prevalence, complication number, and difficulties in treatment require further study and deeper understanding of reparative osteogenesis mechanisms under chronic hyperglycemia and finding new effective and affordable approaches to their treatment. Therefore, the aim of our work was to study the histological, ultramicroscopic, and histomorphometric features of reparative osteogenesis in rats with chronic hyperglycemia (CH), as well as to investigate the possibility of platelet-rich plasma (PRP) use in a fracture area in order to correct the negative effects of CH on reparative osteogenesis processes. .

The histological and electron microscopic study of the parotid salivary gland in dehydrated rats of different ages.

Objective: Introduction: Water-salt metabolism disorders is one of the main factor of salivary gland pathology development. The aim: To study the morphological structure of the parotid salivary gland of young, mature and old rats at micro- and ultrastructural levels under water deprivation.

Patients And Methods: Materials and methods: The experiment was carried out on thirty six laboratory male rats of different ages (young, mature and old).

[The association between enpp1 rs997509 polymorphism and type 2 diabetes mellitus development in ukrainian population].

Objective: Introduction: Genome-Wide Association Studies have identified a large number of polymorphic loci associated with type 2 diabetes mellitus (T2DM). Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) gene is one of the candidate genes which have primary importance in T2DM development. Several studies revealed the association between ENPP1 polymorphisms, including rs997509, and T2DM, obesity, insulin resistance and metabolic syndrome in different populations.