Publications by authors named "Genki Yamaguchi"
Article Synopsis
- Researchers analyzed serum metabolites from 83 patients to find early markers for predicting SARS-CoV-2 infection severity.
- High levels of de-aminated amino acid catabolites, linked to nucleotide synthesis, were identified as potential early indicators of severe disease and correlated with viral load.
- Animal studies showed that amino acid de-amination and nucleotide synthesis led to abnormal cell growth in the lungs, suggesting that early lung tissue changes could indicate future inflammation and disease progression.
-Amino acids (-AAs) have various functions in mammals and microbes. -AAs are produced by gut microbiota and can act as potent bactericidal molecules. Thus, -AAs regulate the ecological niche of the intestine; however, the actual impacts of -AAs in the gut remain unknown.
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- Microbiota-accessible carbohydrates (MACs), like l-arabinose and sucrose, can positively influence gut health and regulate body weight, but their specific effects are not fully understood.
- Research shows that l-arabinose helps reduce obesity in mice when combined with sucrose, by promoting beneficial gut bacteria that produce short-chain fatty acids (SCFAs) like acetate and propionate.
- The study indicates that l-arabinose and sucrose work together to enhance SCFA production through different metabolic pathways in gut bacteria, suggesting the potential for MACs to be used for targeted gut health improvements.
Infectious diarrhea is one of the most important health problems worldwide. Although nutritional status influences the clinical manifestation of various enteric pathogen infections, the effect of diet on enteric infectious diseases remains unclear. Using a fatal infectious diarrheal model, we found that an amino acid-based diet (AD) protected susceptible mice infected with the enteric pathogen .
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