Publications by authors named "Genki Imaizumi"
Aquaporin (Aqp) 10 is a member of the aquaglyceroporin subfamily of water channels, and human Aqp10 is permeable to solutes such as glycerol, urea, and boric acid. Tetrapods have a single aqp10 gene, whereas ray-finned fishes have paralogs of this gene through tandem duplication, whole-genome duplication, and subsequent deletion. A previous study on Aqps in the Japanese pufferfish Takifugu rubripes showed that one pufferfish paralog, Aqp10.
View Article and Find Full Text PDFMarine teleosts ingest large amounts of seawater containing various ions, including 0.4 mM boric acid, which can accumulate at toxic levels in the body. However, the molecular mechanisms by which marine teleosts absorb and excrete boric acid are not well understood.
View Article and Find Full Text PDFArticle Synopsis
- - Boric acid is an important micronutrient but can be toxic at high levels, and how it moves in animal cells is not fully understood.
- - Researchers studied human aquaporins (AQPs) in frog oocytes to find out which AQPs allow boric acid transport, discovering that AQP3, 7, 8, 9, and 10 significantly increased boric acid permeability.
- - The study confirmed that these specific AQPs transport boric acid (B(OH) ) rather than borate ions (B(OH) ), suggesting they function as boric acid channels in human cells.