Effects of treatment interruption due to patient convenience on treatment of once a week teriparatide.

Objectives: Once-weekly teriparatide (W-TPTD) is an effective drug for patients with osteoporosis; however, some patients discontinue W-TPTD owing to its adverse drug reactions (ADRs). Sequential treatment with W-TPTD and antiresorptive therapy may be effective in treating such patients. In this study, we evaluate the efficacy of this sequential treatment regimen.

Hip structure analysis of bisphosphonate-treated Japanese postmenopausal women with osteoporosis.

The purpose of this study was to clarify the effects of a 1-year treatment with either alendronate or risedronate on the proximal femoral geometry among Japanese women with osteoporosis by hip structure analysis. Postmenopausal women who had taken at least 90% of their prescription for alendronate (35 mg/week, 94 patients) or risedronate (17.5 mg/week, 181 patients) for 1 year were retrospectively analyzed.

[QOL in osteoporotic patients with vertebral fractures].

Vertebral fractures leading to low back pain, spinal deformity, gastroesophageal reflux disease, and cardiopulmonary dysfunctions decrease the quality of life (QOL) in patients with osteoporosis. We had investigated the change of QOL in osteoporosis patients with back pain for 6 months. The relief of the pain improved "activities of daily living" , but did not "leisure, social activities" , "health perception" , "posture, figure" , and "fall, mental factors" .

Osteoporosis in 5 elderly women with pubic osteolysis.

5 elderly women developed pubic osteolysis after spontaneous fracture of the pubic bone. Radiographs showed gradual progression of the osteolysis, followed by callus formation, and bone union after 4-5 months. Bone mineral density was low in all patients.

Chemokine profile of herniated intervertebral discs infiltrated with monocytes and macrophages.

Study Design: Herniated lumbar disc specimens were analyzed using reverse transcriptase-polymerase chain reaction to determine the profile of chemokine expression.

Objective: To investigate the mechanism underlying the recruitment of inflammatory cells into herniated discs during the process of spontaneous regression.

Summary Of Background Data: Spontaneous regression of herniated intervertebral discs has been increasingly reported.