Publications by authors named "Genichi Kanai"

Article Synopsis
  • The endoplasmic reticulum (ER) is crucial for synthesizing membrane and secretory proteins, but improper folding leads to ER stress.
  • Recent studies have linked ER stress to various diseases, highlighting the need for better understanding through in vivo research.
  • This report introduces Raman spectroscopy as a method to detect ER stress in living organisms, showing that specific Raman bands decrease in relation to ER stress, offering a non-transgenic approach for studying this condition.
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Endoscopy can be used for sequential observation of gastric carcinogenesis in animal models. In the present study, we applied endoscopic examination and biopsy technique on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach cancer in rats using a newly-developed flexible 2.5 mm endoscope.

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A small endoscope system equipped with a micro Raman probe is developed for in vivo Raman measurements in living rats. The measurements are done under anesthesia and artificial respiration to minimize the impact on the rats. Raman spectra of living rat esophagus and stomach are successfully measured.

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