Polyphyllin II inhibits NLPR3 inflammasome activation and inflammatory response of -infected human bronchial epithelial cells.

Background: The bronchial infection by is increasing in prevalence and severity worldwide. Despite appropriate tuberculosis treatment, most patients still develop bronchial stenosis, which often leads to disability. Polyphyllin II (PP2) is a steroidal saponin extracted from Rhizoma Paridis.