Increased health risk from co-exposure to polycyclic aromatic hydrocarbons, phthalates, and per- and polyfluoroalkyl substances: Epidemiological insight from e-waste workers in Hong Kong.

The alarming surge in electronic waste (e-waste) in Hong Kong has heightened concerns regarding occupational exposure to a myriad of pollutants. Among these, polycyclic aromatic hydrocarbons (PAHs), phthalates (PAEs), and per- and polyfluoroalkyl substances (PFASs) are prevalent and known for their harmful effects, including the induction of oxidative stress and DNA damage, thereby contributing to various diseases. This study addresses gaps in knowledge by investigating exposure levels of these pollutants-measured via hydroxylated PAHs (OH-PAHs), phthalate metabolites (mPAEs), and PFASs-in urine from 101 e-waste workers and 100 office workers.

Individual-level noise exposure and its association with sleep quality and duration: A cross-sectional study using real-time data.

As urban populations grow, the problem of noise pollution becomes more significant. The limited number of epidemiological studies linking individual-level dynamic noise exposure to sleep highlights a gap in our understanding of how individual-level noise exposure impact sleep quality and duration. A cross-sectional survey was conducted in Hong Kong, and portable noise sensors were used to record participants' real-time noise exposure.

Urinary metals and their associations with DNA oxidative damage among e-waste recycling workers in Hong Kong.

Recycling electronic waste (e-waste) poses risks of metal exposure, potentially leading to health impairments. However, no previous study has focused on this issue in Hong Kong. Therefore, from June 2021 to September 2022, this study collected urine samples from 101 e-waste workers and 100 office workers in Hong Kong to compare their urinary levels of metals using ICP-MS.

Association of residential greenness with incident allergic rhinitis among adults: A prospective analysis of UK Biobank.

Background: Limited studies have assessed the impact of residential greenness exposure on allergic rhinitis in adults, and its relationship with ambient air pollutants remains unknown.

Objective: To investigate the association of residential greenness with allergic rhinitis incidence and explore the mediation effects of ambient air pollutants in adults using data from a prospective cohort study in UK Biobank.

Methods: Greenness was defined as the area-weighted mean of greenness coverage based on the land used data from the Generalized Land Use Database for England (GLUD) 2005 in the UK Biobank.

Estimated daily intake and cumulative risk assessment of organophosphate esters and associations with DNA damage among e-waste workers in Hong Kong.

Organophosphate esters (OPEs) are extensively used as additives in various products, including electronic equipment, which becomes e-waste when obsolete. Nevertheless, no study has evaluated OPEs exposure levels and the related health risks among e-waste workers in Hong Kong. Therefore, 201 first-spot morning urine samples were collected from 101 e-waste workers and 100 office workers to compare eight urinary OPE metabolites (mOPEs) levels in these groups.

Assessing Neurobehavioral Alterations Among E-waste Recycling Workers in Hong Kong.

Background: E-waste workers in Hong Kong are handling an unprecedented amount of e-waste, which contains various neurotoxic chemicals. However, no study has been conducted to evaluate the neurological health status of e-waste workers in Hong Kong. This study aimed to evaluate the prevalence of neurobehavioral alterations and to identify the vulnerable groups among Hong Kong e-waste workers.

All cause and cause specific mortality associated with transition to daylight saving time in US: nationwide, time series, observational study.

Objectives: To estimate the association between the transition to daylight saving time and the risks of all cause and cause specific mortality in the US.

Design: Nationwide time series observational study based on weekly data.

Setting: US state level mortality data from the National Center for Health Statistics, with death counts from 50 US states and the District of Columbia, from the start of 2015 to the end of 2019.

Association of preserved ratio impaired spirometry with mortality: a systematic review and meta-analysis.

Background: Preserved ratio impaired spirometry (PRISm) is prevalent within the general population. Increased mortality has been reported among subjects with PRISm, but the evidence has never been summarised. This systematic review aims to synthesise evidence on the association between PRISm and the risk of all-cause, cardiovascular and respiratory-related mortality.

Effectiveness of the booster dose of inactivated COVID-19 vaccine against Omicron BA.5 infection: a matched cohort study of adult close contacts.

Background: Although COVID-19 vaccines and their booster regimens protect against symptomatic infections and severe outcomes, there is limited evidence about their protection against asymptomatic and symptomatic infections in real-world settings, particularly when considering that the majority of SARS-CoV-2 Omicron infections were asymptomatic. We aimed to assess the effectiveness of the booster dose of inactivated vaccines in mainland China, i.e.

Association between matched chronotype and poor mental health among shift workers: a systematic review and meta-analysis.

Background: Nearly 0.7 billion workers are involved in the shift work system, leading to concerns about its potential impacts on the large-scale population mental health. This study aimed to synthesise evidence of the associations between matched chronotype and the risk of poor mental health among shift workers.

Association of circadian rhythm with mild cognitive impairment among male pneumoconiosis workers in Hong Kong: a cross-sectional study.

Weakened circadian activity rhythms (CARs) were associated with mild cognitive impairment (MCI) in the general population. However, it remains unclear among pneumoconiosis patients. We aimed to address this knowledge gap.

Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish.

Heavy metal pollution has become a serious environmental concern and a threat to public health. Three of the most common heavy metals are cadmium (Cd), lead (Pb), and manganese (Mn). Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor activated in the response to oxidative stress.

Differences in Sleep Patterns and Mental Health Problems During Different Periods of COVID-19 Outbreak Among Community-Dwelling Older Men in Hong Kong.

To determine the association of sleep with mental health among Hong Kong community-dwelling older men in the context of the COVID-19 pandemic. This additional analysis was derived from the community-dwelling men aged >60 recruited during three COVID-19 outbreaks (i.e.

Neurotoxicity and gene expression alterations in zebrafish larvae in response to manganese exposure.

Manganese (Mn) is an essential trace element, but excessive exposure can damage mental, cognitive, and motor functions. Although many studies have reported the toxicity of Mn, the underlying mechanism remains unclear. Here, wild-type and/or Tg(NBT:DsRed) zebrafish embryos/larvae were exposed to different dosages of Mn to determine the effects on mortality, malformation, and hatching rates.

The role of ambra1 in Pb-induced developmental neurotoxicity in zebrafish.

Lead is a highly toxic metal that displays developmental neurotoxicity. Ambra1 plays a crucial role in embryonic neural development. At present, the role of Ambra1 in lead-induced developmental neurotoxicity remains unknown.

Joint effect between bisphenol A and alcohol consumption on benign prostatic hyperplasia: A case-control study in Hong Kong Chinese males.

Background: Whether bisphenol A (BPA) exposure is a contributing factor to benign prostatic hyperplasia (BPH) remains unclear. This study evaluated the association between chronic BPA exposure and BPH risk, and explored whether this association was modified by alcohol drinking.

Methods: This study included a total of 650 BPH cases and 650 controls recruited from the same hospital in Hong Kong during 2011-2016.

Joint toxicity of lead and cadmium on the behavior of zebrafish larvae: An antagonism.

Although the individual toxicity of lead (Pb) and cadmium (Cd) was intensively studied, little is known about their joint toxicity on the development of circadian behavioral rhythm. Therefore, we co-exposed zebrafish to Pb and Cd to investigate the alterations of behavioral rhythm and the potential mechanism. Inductively coupled plasma mass spectrometry analysis was used to detect the internal exposure level of heavy metals.

A re-analysis in exploring the association between temperature and COVID-19 transmissibility: an ecological study with 154 Chinese cities.

https://bit.ly/3esw8rc

A protective role of autophagy in Pb-induced developmental neurotoxicity in zebrafish.

Lead (Pb) is one of the most toxic heavy metals and has aroused widespread concern as it can cause severe impairments in the developing nervous system. Autophagy has been proposed as an injury factor in Pb-induced neurotoxicity. In this study, we used zebrafish embryo as a model, measured the general toxic effects of Pb, and investigated the effect of Pb exposure on autophagy, and its role in Pb-induced developmental neurotoxicity.