Publications by authors named "Gengyu Cen"
Objective: To investigate the pathogenesis of cancer-related ischemic stroke (CRIS) and to search for reliable biomarkers of CRIS.
Methods: Patients with CRIS, only-cancer and only-ischemic stroke who were hospitalized in the First Affiliated Hospital of Guangxi Medical University from May 2022 to January 2024 were recruited, and laboratory and clinical data of the three groups were collected. Peripheral venous blood was collected and enzyme-linked immunosorbent assay (ELISA) was used to detect markers of coagulation (D-dimer) and endothelial integrity (intercellular adhesion molecule-1 (ICAM-1)).
Background: Stroke is one of the leading causes of disability and mortality worldwide.
Objective: To identify the regulatory network of microRNAs (miRNAs) and mRNAs to clarify molecular mechanisms in stroke.
Methods: Four miRNA datasets and two mRNA datasets of stroke were downloaded from the GEO database.
Article Synopsis
- - This study explored the connection between hypercoagulability and cerebral infarction in patients with hepatocellular carcinoma (HCC) using a technique called thromboelastography (TEG).
- - Researchers compared data from three groups: patients with HCC-related cerebral infarction, HCC patients without cerebral infarction, and acute cerebral infarction patients without HCC, finding that certain blood parameters were significantly higher in the HCRCI group.
- - The study identified key risk factors associated with HCRCI, including higher levels of neutrophils, D-dimer, and a specific TEG measurement called maximum amplitude (MA), which helps clinicians better assess the risk of cerebral infarction in HCC patients.
Cyclin B2 (CCNB2) belongs to type B cell cycle family protein, which is located on chromosome 15q22, and it binds to cyclin-dependent kinases (CDKs) to regulate their activities. In this study, 103 high-throughput datasets related to all subtypes of lung cancer (LC) and cerebral ischemic stroke (CIS) with the data of CCNB2 expression were collected. The analysis of standard mean deviation (SMD) and summary receiver operating characteristic (SROC) reflecting expression status demonstrated significant up-regulation of CCNB2 in LC and CIS (Lung adenocarcinoma: SMD = 1.
View Article and Find Full Text PDFThe purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. The Gene Expression Omnibus (GEO) database was utilized to obtain four COVID-19 datasets and two stroke datasets. Thereafter, we identified key modules via weighted gene co-expression network analysis, following which COVID-19- and stroke-related crucial modules were crossed to identify the common genes of COVID-19-related stroke.
View Article and Find Full Text PDFObjective: To investigate the clinical features, risk factors and underlying pathogenesis of cancer related subarachnoid hemorrhage (SAH).
Methods: Clinical data of SAH in patients with active cancer from January 2010 to December 2020 at four centers were retrospectively reviewed. Patients with active cancer without SAH were matched to SAH patients with active cancer group.
Objectives: Some acute ischemic stroke (AIS) patients still suffer from early neurological deterioration (END) after receiving intravenous thrombolysis (IVT), and these patients often have a poor prognosis. The purpose of our study is to observe the efficacy and safety of human urinary kallidinogenase (HUK) treatment in patients with END.
Methods: This was a retrospective analysis and 49 patients with END who met the inclusion criteria were divided into the observation group and the control group.
Clinical features of intracerebral hemorrhage in patients with colorectal cancer and its underlying pathogenesis.
World J Gastrointest Oncol
December 2021
Background: The diagnosis of both cancer and intracerebral hemorrhage (ICH) in the same patient is not uncommon, but the clinical features and pathogenesis of patients with colorectal cancer (CRC) and ICH are still not well known.
Aim: To investigate the clinical features and underlying pathogenesis of ICH in patients with CRC.
Methods: A retrospective review of CRC patients complicated with ICH from three centers between January 2014 and December 2020 was performed.