Publications by authors named "Gengqiang Yang"
Background: Radiotherapy is one of the main treatments for non-small cell lung cancer (NSCLC), and radiosensitivity is a determinant of its efficacy. Therefore, enhancing the radiosensitivity is of great significance to improve the clinical efficacy of non-small cell lung cancer (NSCLC).
Purpose: This study intended to investigate the radiosensitisation effect and mechanism of Guiqi Baizhu decoction (GQBZD) on non-small cell lung cancer (NSCLC) and the role of hypoxia-inducible factor-1 alpha (HIF-1α)/DNA-dependent protein kinase catalytic subunit (DNA-PKcs) axis-mediated DNA non-homologous end joining (NHEJ) repair in NSCLC radiotherapy.
The impact of X-rays on cardiac hydrometabolism and the regulatory role of AS-IV.
Int Immunopharmacol
December 2024
Background: Radiation-induced cardiac injury has emerged as a significant pathological entity, with many studies focusing on the fibrotic changes in myocardial tissue. However, these do not offer solutions for the clinical prevention and treatment of radiation-induced heart disease. Regulating hydrometabolism presents a potential therapeutic target for the management of cardiovascular diseases.
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- Existing studies show that compounds from Astragalus membranaceus (AM) help reduce radiation damage, but there hasn't been research on how isoliquiritigenin (ISL) affects bone marrow stem cells in carbon ion radiation therapy for lung cancer.
- This study aimed to explore ISL's ability to enhance the effectiveness of radiotherapy while protecting stem cells from damage, using various experimental methods and models.
- The findings indicate that ISL significantly improves the anti-tumor effects of carbon ion radiotherapy and decreases radiation harm to bone marrow stem cells, suggesting its potential as a radiosensitizer in lung cancer treatment.
Cathepsin B (CTSB) is a key lysosomal protease that plays a crucial role in the development of cancer. This article elucidates the relationship between CTSB and cancer from the perspectives of its structure, function, and role in tumor growth, migration, invasion, metastasis, angiogenesis and autophagy. Further, we summarized the research progress of cancer treatment related drugs targeting CTSB, as well as the potential and advantages of Traditional Chinese medicine in treating tumors by regulating the expression of CTSB.
View Article and Find Full Text PDFCardiovascular diseases are the main killers threatening human health. Many studies have shown that abnormal energy metabolism plays a key role in the occurrence and development of acute and chronic cardiovascular diseases. Regulating cardiac energy metabolism is a frontier topic in the treatment of cardiovascular diseases.
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