Publications by authors named "Gengmin Niu"
Article Synopsis
- The study focuses on establishing dosimetric limits to reduce the risk of developing significant brachial plexopathy (nerve damage) in patients undergoing stereotactic body radiation therapy (SBRT) for lung cancer.
- Data from 349 patients with apical lung tumors who received SBRT were analyzed, identifying the maximum radiation doses that could be tolerated by the brachial plexus without leading to severe complications.
- Results indicated that a 10% risk of serious nerve damage occurs with maximum doses ranging from 20.7 to 42.7 Gy, depending on the number of treatment fractions, providing critical guidelines for safer radiation therapy practices.
Although intravenous bevacizumab (IVBEV) is the most promising treatment for cerebral radiation necrosis (CRN), there is no conclusion on the optimal dosage. Our retrospective study aimed to compare the efficacy and safety of high-dose with low-dose IVBEV in treating CRN associated with radiotherapy for brain metastases (BMs). This paper describes 75 patients who were diagnosed with CRN secondary to radiotherapy for BMs, treated with low-dose or high-dose IVBEV and followed up for a minimum of 6 months.
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- The study focuses on the importance of accurately contouring the brachial plexus (BP) to assess toxicity and identify metrics for predicting radiation-induced brachial plexopathy (RIBP) after targeted radiotherapy.
- Patients with a specific planning target volume (PTV) close to the BP were analyzed, using established radiation therapy atlases for contouring.
- Results showed that maximum doses to the BP were linked to a significant risk of RIBP, highlighting that relying on subclavian-axillary veins for dosimetry may underestimate risk, especially in certain patient groups.