A novel biomimetic nanofibrous cardiac tissue engineering scaffold with adjustable mechanical and electrical properties based on poly(glycerol sebacate) and polyaniline.

Biomaterial tissue engineering scaffolds play a critical role in providing mechanical support, promoting cells growth and proliferation. However, due to the insulation and inappropriate stiffness of most biomaterials, there is an unmet need to engineer a biomimetic nanofibrous cardiac tissue engineering scaffold with tailorable mechanical and electrical properties. Here, we demonstrate for the first time the feasibility to generate a novel type of biocompatible fibrous scaffolds by blending elastic poly(glycerol sebacate) (PGS) and conductive polyaniline (PANI) with the help of a nontoxic carrier polymer, poly (vinyl alcohol) (PVA).

In vitro fatigue behavior and in vivo osseointegration of the auxetic porous bone screw.

The incidence of screw loosening, migration, and pullout caused by the insufficient screw-bone fixation stability is relatively high in clinical practice. To solve this issue, the auxetic unit-based porous bone screw (AS) has been put forward in our previous work. Its favorable auxetic effect can improve the primary screw-bone fixation stability after implantation.

Degradation behavior of 2D auxetic structure with biodegradable polymer under mechanical stress.

Coronary heart disease is serious harm to human health. Vascular scaffold implantation is the main treatment. Biodegradable polymers are widely used in vascular scaffolds for good biodegradability and biocompatibility.

1Biomaterial inks for extrusion-based 3D bioprinting: Property, classification, modification, and selection.

Three-dimensional (3D) extrusion-based bioprinting is the most widely used bioprinting technology to fabricate bionic tissue or organ constructs by combining biomaterial ink and living cells for tissue engineering and regenerative medicine. One critical issue of this technique is the selection of suitable biomaterial ink to simulate extracellular matrix (ECM) that provides mechanical support for cells and regulates their physiological activities. Previous studies have demonstrated that it is an enormous challenge to form and maintain reproducible 3D constructs and eventually achieve the balance among biocompatibility, mechanical properties, and printability.

Graphdiyne oxide elicits a minor foreign-body response and generates quantum dots due to fast degradation.

Graphdiyne (GDY) is a novel two-dimensional (2D) carbon allotrope that has attracted much attention in materials, physics, chemistry, and microelectronics for its excellent properties. Much effort has been devoted to exploring the biomedical applications of GDY in 2D carbon nanomaterials, especially for smart drugs and gene delivery. However, few studies have focused on the biocompatibility and potential environmental hazards of GDY and its derivatives.