ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells.

Identifying novel targets for molecular radiosensitization is critical for improving the efficacy of colorectal cancer (CRC) radiotherapy. Alpha-thalassemia/mental retardation X-linked (ATRX), a member of the SWI/SNF-like chromatin remodeling protein family, functions in the maintenance of genomic integrity and the regulation of apoptosis and senescence. However, whether ATRX is directly involved in the radiosensitivity of CRC remains unclear.

Biomimetic dual-oriented/bilayered electrospun scaffold for vascular tissue engineering.

Natural blood vessels have a multi-layered, cell-specific oriented spatial structure, mimicking of this structure is a promising way for blood vessel regeneration. In this study, a newly developed dual-oriented/bilayered small-diameter tubular scaffold was electrospun using a mixture of poly (ε-caprolactone) (PCL), poly (D, L-lactide-co-glycolide) (PLGA) and gelatin. The nanofiber orientations of the bilayers were spatially perpendicular to each other, aiming at guiding cell-specific orientation of smooth muscle cells (SMCs) and endothelial cells (ECs) respectively.

Deep Learning Method Based on Gated Recurrent Unit and Variational Mode Decomposition for Short-Term Wind Power Interval Prediction.

Wind power interval prediction (WPIP) plays an increasingly important role in evaluations of the uncertainty of wind power and becomes necessary for managing and planning power systems. However, the intermittent and fluctuating characteristics of wind power mean that high-quality prediction intervals (PIs) production is a challenging problem. In this article, we propose a novel hybrid model for the WPIP based on the gated recurrent unit (GRU) neural networks and variational mode decomposition (VMD).

[Development and Testing of Multi-mode Elbow Joint Muscle Strength Training Device].

Muscle strength training plays an important role in improving limb movement function, preventing muscle atrophy and promoting muscle function recovery in patients with various bone and joint diseases. The sports function of elbow joint is closely related to people's daily life activity ability. At present, Chinese muscle strength training devices are depended on import.

ROS Induced by KillerRed Targeting Mitochondria (mtKR) Enhances Apoptosis Caused by Radiation via Cyt c/Caspase-3 Pathway.

During radiotherapy, reactive oxygen species- (ROS-) induced apoptosis is one of the main mechanism of radiation. Based on KillerRed which can induce ROS burst in different cell substructures, here we hypothesized that KillerRed targeting mitochondria (mtKR) could induce ROS to enhance apoptosis by radiation. In this study, empty vector, mtKR, and mtmCherry plasmids were successfully constructed, and mitochondrial localization were detected in COS-7 and HeLa cells.