Quantitative proteomic analysis for characterization of protein components related to dough quality and celiac disease in wheat flour, dough, and heat-treated dough.

High-sensitivity 4D label-free proteomic technology was used to identify protein components related to gluten quality and celiac disease (CD) in strong-gluten wheat cultivar KX 3302 and medium-gluten wheat cultivar BN 207. The highly expressed storage protein components in KX3302 were high-molecular-weight-glutenin-subunits (HMW-GSs), α-gliadin, and globulin, whereas those in BN207 were γ-gliadin, low-molecular-weight-glutenin-subunits (LMW-GSs) and avenin-like proteins. In addition, BN207 had more upregulated metabolic proteins than KX3302.

Impact of the COVID-19 pandemic on the demographic and disease burden of pediatric malignant solid tumors in China: a single-center, cross-sectional study.

Background: With the development of the novel coronavirus disease 2019 (COVID-19), China implemented measures in an attempt to control the infection rate. We conducted a single-center, cross-sectional study to ascertain the impact of the COVID-19 pandemic on the equitable availability of medical resources for children diagnosed with malignant solid tumors in China.

Methods: Data on the demographics, clinical characteristics, and medical expenses of 876 patients diagnosed with neuroblastoma, rhabdomyosarcoma (RMS), Wilms tumor, hepatoblastoma (HB), Ewing sarcoma (ES), and central nervous system (CNS) tumors from 2019 to 2021, during the COVID-19 pandemic, were retrospectively collected from the National Center for Children's Health.

Wheat GSPs and Processing Quality Are Affected by Irrigation and Nitrogen through Nitrogen Remobilisation.

The rheological properties and end-use qualities of many foods are mainly determined by the types and levels of grain storage proteins (GSPs) in wheat. GSP levels are influenced by various factors, including tillage management, irrigation, and fertiliser application. However, the effects of irrigation and nitrogen on GSPs remain unclear.

Lipidomics-based insights into the physiological mechanism of wheat in response to heat stress.

Lipids are the main components of plant cell biofilms and play a crucial role in plant growth, Understanding the modulation in lipid profiles under heat stress can contribute to understanding the heat tolerance mechanisms in wheat leaves. In the current study, two wheat cultivars with different heat tolerance levels were treated with optimum temperature (OT) and high temperature (HT) at the flowering stage, and the antioxidant enzyme activity in the leaves and the grain yield were determined. Further, lipidomics was studied to determine the changes in lipid composition in the leaves.

Long-term conservation tillage improves soil stoichiometry balance and crop productivity based on a 17-year experiment in a semi-arid area of northern China.

Although conservation tillage has been widely implemented to address the challenge to improve crop yield and soil quality with fewer environmental costs, its long-term effects on crop yields and soil stoichiometry balance remain uncertain. Here, four different long-term (17-year) tillage practices (conventional tillage (CT), deep scarification (DS), no tillage (NT), and ridge tillage (RT)) were conducted in northern China to evaluate their effects on crop yield, soil nutrients, C sequestration, and soil stoichiometry. The conservation tillage (DS, NT, and RT) increased the recent 5-year average yields by 12.

FOXM1 and CENPF are associated with a poor prognosis through promoting proliferation and migration in lung adenocarcinoma.

Lung adenocarcinoma (LUAD) is a clinically challenging disease due to its poor prognosis and limited therapeutic methods. The aim of the present study was to identify prognosis-related genes and therapeutic targets for LUAD. Raw data from the GSE32863, GSE41271 and GSE42127 datasets were downloaded from the Gene Expression Omnibus database.

Analysis of Physiological Indicators Associated with Drought Tolerance in Wheat under Drought and Re-Watering Conditions.

Wheat ( L.) production is severely threatened by an increase in the frequency of drought events. It is crucial to determine stable and effective morphological, physiological, and associated oxidative stress indicators, to evaluate the drought tolerance of wheat for breeding and cultivation.

A novel onlay urethroplasty for hypospadias with mild chordee after degloving: modified for complete removal of scar tissue underlying the urethral plate and for long-term outcomes.

Urethral plate (UP)-preserving urethroplasty is simple and has few complications, but it may affect the development of penis in the long term and lead to recurrent chordee. In this study, we used obliquely cut UP to repair hypospadias with mild chordee after degloving (15°-30°) and compared the results with onlay urethroplasty to explore its rationality and feasibility. Between April 2018 and October 2020, 108 hypospadias patients underwent onlay urethroplasty or modified onlay urethroplasty.

Soil organic carbon and nitrogen storage under a wheat ( L.)-maize ( L.) cropping system in northern China was modified by nitrogen application rates.

Field cultivation practices have changing the carbon and nitrogen cycles in farmland ecosystem, soil organic carbon (SOC) and total nitrogen (TN) were the important parameters in maintaining soil quality and increasing agricultural productivity, however, N application's effects on the SOC and TN storage capacity under intensive wheat-maize cropping system remain unclear. Therefore, we investigated the characteristics and relationships of SOC and TN for wheat-maize cropping system under nitrogen treatments. In doing so, continuous applications of four nitrogen application rates were examined: 0, 180, 240 and 300 kg ha (N0, N180, N240 and N300, respectively).

[Treatment of severe hypospadias and analysis of related problems].

Hypospadias is one of the common congenital malformations of the urogenital system in children, with a high incidence and an increasing trend. And the incidence rate of severe hypospadias is increasing year by year, which seriously affects the penile development of the patient. With deepened understanding of hypospadias, accumulated experience in its diagnosis and treatment, and continuous improvement of surgical strategies, the success rate of surgical repair of hypospadias has been elevated to a certain extent.

Comparative study of one-stage and the novel two-stage urethroplasty using the transected urethral plate and transverse preputial island flap (TPIF) for severe hypospadias: a single-center experience.

Background: To evaluate a novel two-stage method of urethroplasty using a transected urethral plate and transverse preputial island flap (TPIF) for proximal hypospadias with severe chordee.

Methods: We retrospectively analyzed 91 cases of proximal hypospadias, who had undergone either one-stage or two-stage urethroplasty. Comparisons between the two groups were made based on age, glans diameter, the length of the urethral defect, and the rate of complications.

Patient transfer influences the prognosis of pediatric patients operated for testicular torsion: a single-center experience.

Background: Testicular torsion (TT) remains an emerging issue for pediatric patients. This study's objective was to determine risk factors of TT outcomes in the Chinese pediatric cohort from a single center.

Methods: We performed a retrospective cohort study of patients who met the inclusion criteria in our center from 2013 to 2018.

Lich-Gregoir vesico-ureteral reimplantation for duplex kidney anomalies in the pediatric population: a retrospective cohort study between laparoscopic and open surgery.

Background: The aim of the study is to compare the Lich-Gregoir vesico-ureteral reimplantation in laparoscopy and open surgery.

Methods: In this case control study, we enrolled pediatric patients who were diagnosed with unilateral duplex kidney and had underwent surgical treatment. The surgical treatments were either conventional open surgery or laparoscopic surgery.

Use of double-J ureteric stents post-laparoscopic pyeloplasty to treat ureteropelvic junction obstruction in hydronephrosis for pediatric patients: a single-center experience.

Objectives: We aimed to investigate the safety concerns associated with placing double-J ureteric stents post-laparoscopic pyeloplasty surgery for congenital ureteropelvic junction obstruction (UPJO) and hydronephrosis.

Methods: A total of 1349 patients with postoperative double-J stent placement at our center were included. Clinical variables for enrolled patients were collected by two independent authors.

Bacterial Community Structure and Predicted Function in Wheat Soil From the North China Plain Are Closely Linked With Soil and Plant Characteristics After Seven Years of Irrigation and Nitrogen Application.

The influence of water and nitrogen (N) management on wheat have been investigated, but studies on the impact of long-term interactive water and N management on microbial structure and function are limited. Soil chemical properties and plants determine the soil microbial communities whose functions involved in nutrient cycling may affect plant productivity. There is an urgent need to elucidate the underlying mechanisms to optimize these microbial communities for agricultural sustainability in the winter wheat production area of the North China Plain.

Effects of High Temperature and Drought Stress on the Expression of Gene Encoding Enzymes and the Activity of Key Enzymes Involved in Starch Biosynthesis in Wheat Grains.

High temperature (HT) and drought stress (DS) play negative roles in wheat growth, and are two most important factors that limit grain yield. Starch, the main component of the wheat [][endosperm, accounts for 65-75% of grain weight, and is significantly influenced by environmental factors. To understand the effects of post-anthesis HT and DS on starch biosynthesis, we performed a pot experiment using wheat cultivar "Zhengmai 366" under field conditions combined with a climate-controlled greenhouse to simulate HT.

Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single-center experience.

Background: Urinary tract infection (UTI) is common in children. The purpose of this retrospective study was to determine the various risk factors that usually affect the prognosis of UTI in children diagnosed with the disease.

Methods: In the present retrospective study, we enrolled all pediatric patients diagnosed with UTI and hospitalized between 1 January 2013 and 31 July 2016 at Nanjing Children's Hospital.

Nrf2 signaling attenuates epithelial-to-mesenchymal transition and renal interstitial fibrosis via PI3K/Akt signaling pathways.

Background: Nrf2 constitutes a therapeutic reference point for renal fibrosis and chronic kidney diseases. Nrf2-related signaling pathways are recognized to temper endothelial-to-mesenchymal transition (EMT) in fibrotic tissue. Nevertheless, the mechanism by which Nrf2 mitigates renal interstitial fibrosis is imprecise.

Characteristics of hydraulic fracture surface based on 3D scanning technology.

[This retracts the article DOI: 10.1098/rsos.171845.

Determining the Optimal N Input to Improve Grain Yield and Quality in Winter Wheat With Reduced Apparent N Loss in the North China Plain.

Excessive or improper nitrogen (N) application rates negatively affect crop production and thereby environmental quality, particularly for winter wheat production in the North China Plain. Therefore, it is very important to optimize N fertilizer input to balance grain yield, environmental risk, and benefits under irrigated conditions. Three long-term stationary field experiments including five N levels, from 0 to 300 kg ha [0 (N0), 90 (N90), 180 (N180), 240 (N240), and 300 (N300) kg ha] were carried out to investigate the effects of N regime on wheat yield, photosynthesis, and N balance at different sites.

Comparative study of urethroplasties to reduce urethral strictures in patients with severe hypospadias.

Objective: Transverse island pedicle flap (TIPF) plus transected urethral plate-preserving urethroplasty is increasingly used for treatment of severe hypospadias. We aimed to reduce the occurrence of urethral strictures in patients undergoing such procedures.

Methods: Sixty-five patients with severe hypospadias were enrolled.

Root Growth, Water and Nitrogen Use Efficiencies in Winter Wheat Under Different Irrigation and Nitrogen Regimes in North China Plain.

Excessive nitrogen (N) application combined with water shortage has a negative effect on crop production, particularly wheat ( L.) production in the North China Plain. This study examined root growth and water and nitrogen use efficiencies in wheat grown on loam soil in the North China Plain, from 2012 to 2014 using a fixed-position experiment initiated in 2010.

Characteristics of hydraulic fracture surface based on 3D scanning technology.

The surface characteristics of fractured specimens are important in hydraulic fracturing laboratory experiments. In this paper, we present a three-dimensional (3D) scanning device assembled to study these surface characteristics. Cube-shaped rock specimens were produced in the laboratory and subjected to triaxial loading until the specimen split in two in a hydraulic fracturing experiment.

Retroperitoneal malignant schwannoma in a child.

Retroperitoneal malignant schwannomas are extremely rare. Only a few cases have been reported, only one of which occurred in a child. We herein report a case of retroperitoneal malignant schwannoma in a 2-year-old boy who presented with a painless mass in the right lumbar region.