USP39/SMC4 promotes hepatoma cell proliferation and 5-FU resistance.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, characterized by a high rate of postoperative recurrence and poor long-term survival outcomes. Structural maintenance of chromosome 4 (SMC4) is frequently overexpressed in various types of cancer and plays a pivotal role in tumor cell growth, migration, and invasion. Bioinformatics analysis has revealed a significant correlation between the tumor-node metastasis (TNM) stage (P < 0.

Des-γ-carboxy Prothrombin in hepatocellular carcinoma post-operative recurrence risk evaluation.

Background: While the value of Des-γ-carboxy prothrombin in hepatocellular carcinoma diagnosis has been widely acknowledged, whether or how Des-γ-carboxy prothrombin could be used in recurrence evaluation remains largely unexplored.

Methods: We performed a multicenter retrospective analysis including an Exploration Cohort (1074 patients, 5133 Des-γ-carboxy prothrombin measurements) and a Validation Cohort (263 patients, 612 Des-γ-carboxy prothrombin measurements) to investigate whether Des-γ-carboxy prothrombin could evaluate patients' prognosis. We introduced the Des-γ-carboxy prothrombin dynamic rate as a normalized quantitative measurement of Des-γ-carboxy prothrombin dynamic change.

Characteristics of airborne particles emitted from typical indoor combustion sources.

Combustion is an important source of indoor emissions, and exposure to combustion emissions not only concerns the quality of life of individuals but also directly affects the overall health level of society. To date, very few studies have examined the size-resolved emission characteristics of airborne particulate matter (PM) emitted from indoor sources. The study examined PM emissions from the specified combustion sources.

Tumour protein p53-activated lncRNA PGM5-AS1 suppresses lung cancer growth and stemness by targeting R-spondin1 microRNA-1247-5p.

Objective: This study was to investigated the inhibitory role of the tumour protein p53 (TP53)-activated PGM5-AS1 in lung cancer (LC) cell proliferation, invasion, and CSC-like properties and its underlying mechanisms.

Methods: The effect of PGM5-AS1 on LC cell development was determined. Stem cell markers, aldehyde dehydrogenase activity in cells were tested, as well as the ability of stem cells to form spheroids.

Development-driven Diffusion Model for Longitudinal Prediction of Fetal Brain MRI with Unpaired Data.

Longitudinal magnetic resonance imaging (MRI) is essential for studying the early development of the brain, as it allows to observe and analyze how the brain changes over time. Unfortunately, existing cohort research suffers from lacking sufficient MRI data for studying the development of fetal brains. Apart from research data, a viable alternative is the use of large-scale clinical fetal brain MRI data, which is currently the primary source for longitudinal studies.

Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity.

Prolactin-releasing peptide receptor (PrRPR), a notable member of the class A peptide-GPCR (G-protein-coupled receptor) family, regulates diverse physiology functions upon activation by PrRP. Herein, we reveal that PrRPR could engage with not only the G pathway but also the G pathway. We further resolve the structures of the PrRPR-G and PrRPR-G complexes using cryoelectron microscopy (cryo-EM), with PrRP31 as the endogenous ligand.

Evaluating the effectiveness of ultrasound-assisted wound debridement in managing diabetic foot ulcers: A systematic review and meta-analysis.

Background: Diabetic foot ulcers (DFUs) present a significant clinical challenge due to their high prevalence and profound impact on morbidity. Ultrasound-assisted wound debridement (UAWD) has emerged as a potential therapeutic modality to improve healing outcomes in DFU management.

Aim: To evaluate the efficacy of UAWD in treating DFUs on wound closure rates, treatment duration, and quality of life outcomes.

Association between Healthy Eating Index-2020, alternative Mediterranean Diet scores, and gastrointestinal cancer risk in NHANES 2005-2018.

Diet quality is closely related to the occurrence of gastrointestinal (GI) cancers; however, few studies have investigated the association between the Healthy Eating Index (HEI-2020) and the alternative Mediterranean diet (aMED) scores and GI (GI) cancers. This study aims to assess the association between HEI-2020, aMED scores and GI cancers. Information from a total of 26,320 participants was included in the National Health and Nutrition Examination Survey (NHANES).

Compact and broadband polarization splitter-rotator on thin-film lithium niobate minimized with the fast quasi-adiabatic algorithm.

Polarization splitter-rotators (PSRs) are crucial for on-chip polarization-division multiplexing (PDM) systems. Here, we design and experimentally demonstrate a compact and broadband PSR based on adiabatic mode evolution on a thin-film lithium niobate (TFLN) platform. A novel, to the best of our knowledge, quasi-adiabatic algorithm is proposed to minimize the device size.

Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models.

The immunosuppressive microenvironment in pancreatic cancer, characterized by low tumor-specific T cells and excessive fibrosis, limits the effectiveness of immunotherapy. Here, three datasets and multi-immunofluorescence staining of tissue microarrays in pancreatic cancer indicate that mesothelin (MSLN) expression negatively correlates with cytotoxic T cells in tumor. Anti-MSLN antibody (αMSLN) treatment of pancreatic cancer in vivo can significantly increase T cell infiltration.

Final Overall Survival and Molecular Data Associated with Clinical Outcomes in Patients Receiving Ipatasertib and Abiraterone in the Phase 3 IPATential150 Trial.

Background And Objective: In the phase 3 IPATential150 trial, ipatasertib addition to abiraterone significantly reduced the risk of disease progression in men with metastatic castration-resistant prostate cancer (mCRPC) with PTEN loss on immunohistochemistry (IHC), but not in the intention-to-treat (ITT) population. Here we report the final overall survival (OS) analysis and present results for prespecified and exploratory biomarker analyses.

Methods: Patients were randomized to receive ipatasertib (400 mg once daily) or placebo.

Effect of Temperature on Condensed State Structure and Conductivity Characteristics of Micron-Level Biaxially Oriented Polypropylene Films.

Polymer-based dielectric films are increasingly demanded for devices under high electric fields used in new energy vehicles, photovoltaic grid connections, oil and gas exploration, and aerospace. However, leakage current is one of the significant factors limiting the improvement of the insulation performance. This paper tested the leakage current and condensed state structure characteristics of biaxially oriented polypropylene (BOPP) films and obtained the nonlinear characteristics of leakage current of BOPP films in the range of 40-440 V/μm and 40-110 °C.

Circulating proliferative factors versus portal inflow redistribution: mechanistic insights of ALPPS-derived rapid liver regeneration.

Background: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) can induce accelerated regeneration of future liver remnant (FLR) and effectively reduce the occurrence of liver failure due to insufficient FLR after hepatectomy, thereby increasing the probability of radical resection for previously inoperable patients with liver cancer. However, the exact mechanism by which ALPPS accelerates liver regeneration remains elusive.

Methods: A review of the literature was performed utilizing MEDLINE/PubMed and Web of Science databases in March of 2024.

Evaluation of an enhanced ResNet-18 classification model for rapid On-site diagnosis in respiratory cytology.

Objective: Rapid on-site evaluation (ROSE) of respiratory cytology specimens is a critical technique for accurate and timely diagnosis of lung cancer. However, in China, limited familiarity with the Diff-Quik staining method and a shortage of trained cytopathologists hamper utilization of ROSE. Therefore, developing an improved deep learning model to assist clinicians in promptly and accurately evaluating Diff-Quik stained cytology samples during ROSE has important clinical value.

Efficient and Robust Europium(III)-Based Hybrid Lanthanide Scintillators for Advanced X-Ray Imaging.

Scintillators that convert ionizing radiation into low-energy photons are essential for medical diagnostics and industrial inspections. Despite advances in X-ray scintillators, challenges remain in achieving high efficiency, environmental compatibility, stability, and flexibility. Here, we present experimental investigations of a new type of europium(III)-based hybrid ternary complex scintillators for improved X-ray detection and imaging.

Identifying influential nodes in brain networks via self-supervised graph-transformer.

Background: Studying influential nodes (I-nodes) in brain networks is of great significance in the field of brain imaging. Most existing studies consider brain connectivity hubs as I-nodes such as the regions of high centrality or rich-club organization. However, this approach relies heavily on prior knowledge from graph theory, which may overlook the intrinsic characteristics of the brain network, especially when its architecture is not fully understood.

Investigating the inflammatory mechanism of notoginsenoside R1 in Diabetic nephropathy via ITGB8 based on network pharmacology and experimental validation.

Background: Diabetes often causes diabetic nephropathy (DN), a serious long-term complication. It is characterized by chronic proteinuria, hypertension, and kidney function decline, can progress to end-stage renal disease, lowering patients' quality of life and lifespan. Inflammation and apoptosis are key to DN development.

right posterior sectionectomy during liver procurement based on preoperative 3D planning to prevent extreme large-for-size syndrome in adult-to-adult liver transplantation: a case report.

Background: Large-for-size syndrome (LFSS) is an uncommon but potentially lethal complication following adult liver transplantation (LT). Reduced-size liver transplantation (RSLT) is considered a valuable alternative to delayed fascial closure or mesh closure for preventing LFSS. In this article, we report a successful adult-to-adult RSLT case with right posterior graft sectionectomy using three-dimensional (3D) computer-assisted planning.

Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8CD69 T cells.

Background: Liver metastasis is highly aggressive and immune tolerant, and lacks effective treatment strategies. This study aimed to develop a neoantigen hydrogel vaccine (NPT-gels) with high clinical feasibility and further investigate its efficacy and antitumor molecular mechanisms in combination with immune checkpoint inhibitors (ICIs) for the treatment of liver metastases.

Methods: The effects of liver metastasis on survival and intratumor T-cell subpopulation infiltration in patients with advanced tumors were investigated using the Surveillance, Epidemiology, and End Results Program (SEER) database and immunofluorescence staining, respectively.

Dual relaxation behaviors driven by a homogeneous and stable dual-interface charge layer based on an EGaIn absorber.

Interface engineering, by modulating defect distribution and impedance at interfaces and inducing interfacial polarization, has proven to be an effective strategy for optimizing dielectric properties. However, the inherent incompatibility between heterogeneous phases presents a significant challenge in constructing multi-heterointerfaces and understanding how their distribution influences dielectric performance. Herein, we constructed an EGaIn@Ni/NiO/GaO composite structure by employing a low-intensity ultrasound-assisted galvanic replacement reaction followed by high-temperature annealing.

Research on Behavior Recognition and Online Monitoring System for Liaoning Cashmere Goats Based on Deep Learning.

Liaoning Cashmere Goats are a high-quality dual-purpose breed valued for both their cashmere and meat. They are also a key national genetic resource for the protection of livestock and poultry in China, with their intensive farming model currently taking shape. Leveraging new productivity advantages and reducing labor costs are urgent issues for intensive breeding.

Machine learning models with innovative outlier detection techniques for predicting heavy metal contamination in soils.

Machine learning (ML) models for accurately predicting heavy metals with inconsistent outputs have improved owing to dataset outliers, which influence model reliability and accuracy. A comprehensive technique that combines machine learning and advanced statistical methods was applied to assess data outlier's effects on ML models. Ten ML models with three outlier detection methods predicted Cr, Ni, Cd, and Pb in Narayanganj soils.

Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR.

Advances in singe-particle cryo-electron microscopy (cryo-EM) have made it possible to solve the structures of numerous Family A and Family B G protein-coupled receptors (GPCRs) in complex with G proteins and arrestins, as well as several Family C GPCRs. Determination of these structures has been facilitated by the presence of large extramembrane components (such as G protein, arrestin, or Venus flytrap domains) in these complexes that aid in particle alignment during the processing of the cryo-EM data. In contrast, determination of the inactive state structure of Family A GPCRs is more challenging due to the relatively small size of the seven transmembrane domain (7TM) and to the surrounding detergent micelle that, in the absence of other features, make particle alignment impossible.