Publications by authors named "Genevieve Vallot"
Article Synopsis
- The study aimed to evaluate antipsychotic treatment sequences prior to clozapine initiation, as it’s often prescribed later than recommended after two failed treatments.
- Researchers used data from the French National Health Insurance to analyze treatment patterns among new clozapine users diagnosed with schizophrenia or schizoaffective disorder during 2017-2018.
- Findings revealed 1191 treatment trials among 287 individuals, with distinct clusters identified: younger "less treated" individuals, "more treated" individuals using combinations of medications, and "treatment-stable" older individuals, indicating a need for further research into barriers to earlier clozapine use.
Background: The inherent risk of agranulocytosis associated with clozapine requires the realization of weekly white blood cell monitoring (WBCM) during the 18 first weeks of treatment. The aim of this study was to assess the compliance with WBCM during clozapine initiation for schizophrenia and Parkinson's disease (PD) subjects.
Research Design And Method: The analysis was conducted using SNDS data on a cohort of new users of clozapine in 2018.