Publications by authors named "Genevieve Rocheleau"
Article Synopsis
- ARDS (Acute Respiratory Distress Syndrome) is a critical condition linked mainly to infections like COVID-19, influenza, and bacterial pneumonia, and research is focused on its mechanisms and treatment options.
- The study aims to compare metabolic profiles of ARDS caused by COVID-19, H1N1 influenza, and bacterial pneumonia to understand their unique metabolic pathways.
- Results showed distinct metabolic differences based on the infection type, indicating different underlying mechanisms in ARDS associated with each infectious cause.
Article Synopsis
- The study aimed to assess if angiotensin receptor blockers (ARBs) or ACE inhibitors improve outcomes for hospitalized COVID-19 patients based on sex, while also investigating sex-related differences in the renin-angiotensin system (RAS).
- The research involved a prospective cohort study of 1,686 hospitalized patients across 10 Canadian urban hospitals, measuring baseline characteristics and clinical outcomes related to ARB/ACE inhibitor use.
- Findings revealed that males on ARBs showed reduced need for ventilation and vasopressors compared to those who weren’t on these medications, while no significant benefits were found for females, highlighting a notable sex difference in treatment response.
Background: There have been multiple waves in the COVID-19 pandemic in many countries. We sought to compare mortality and respiratory, cardiovascular and renal dysfunction between waves in 3 Canadian provinces.
Methods: We conducted a substudy of the ARBs CORONA I study, a multicentre Canadian pragmatic observational cohort study that examined the association of pre-existing use of angiotensin receptor blockers with outcomes in adults admitted to hospital with acute COVID-19 up to April 2021 from 9 community and teaching hospitals in 3 Canadian provinces (British Columbia, Ontario and Quebec).
Sociodemographic correlates of engagement in human immunodeficiency virus (HIV) care are well studied, however the association with accessing drug resistance testing (DRT) and the development of drug resistance have not been characterized. Between 1996-2014, 11 801 HIV patients accessing therapy in British Columbia were observed longitudinally. A subset of 9456 patients had testable viral load; of these 8398 were linked to census data.
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