Tractography of the external capsule and cognition: A diffusion MRI study of cholinergic fibers.

Introduction: White matter changes (WMC) in the cholinergic tracts contribute to executive dysfunction in the context of cognitive aging. WMC in the external capsule have been associated with executive dysfunction. The objectives of this study were to: 1) Characterize the lateral cholinergic tracts (LCT) and the superior longitudinal fasciculus (SLF).

White Matter Hyperintensities in Mild Cognitive Impairment and Lower Risk of Cognitive Decline.

Background: White matter hyperintensities (WMH) may have a different impact on cognitive decline depending on strategic localization.

Objective: The goal of this study is to assess the impact of global and cholinergic WMH on cognitive decline of mild cognitive impairment (MCI) patients in the ADNI-1 dataset.

Methods: This is a retrospective analysis of data from a natural history study.