Remote monitoring titration clinic to implement guideline-directed therapy for heart failure patients with reduced ejection fraction: a pilot quality-improvement intervention.

Introduction: Guideline-directed medical therapy (GDMT) is the recommended treatment for heart failure with reduced ejection fraction (HFrEF). However, the implementation remains limited, with suboptimal use and dosing. The study aimed to assess the feasibility and effect of a remote monitoring titration program on GDMT implementation.

Crystal structures of four dimeric manganese(II) bromide coordination complexes with various derivatives of pyridine -oxide.

Four manganese(II) bromide coordination complexes have been prepared with four pyridine -oxides, . pyridine -oxide (PNO), 2-methyl-pyridine -oxide (2MePNO), 3-methyl-pyridine -oxide (3MePNO), and 4-methyl-pyridine -oxide (4MePNO). The compounds are bis-(μ-pyridine -oxide)bis-[aqua-dibromido-(pyridine -oxide)manganese(II)], [MnBr(CHNO)(HO)] (), bis-(μ-2-methyl-pyridine -oxide)bis-[di-aqua-dibromido-manganese(II)]-2-methyl-pyridine -oxide (1/2), [MnBr(CHNO)(HO)]·2CHNO (), bis-(μ-3-methyl-pyridine -oxide)bis-[aqua-dibromido-(3-methyl-pyridine -oxide)manganese(II)], [MnBr(CHNO)(HO)] (), and bis-(μ-4-methyl-pyridine -oxide)bis-[di-bromido-methanol(4-methyl-pyridine -oxide)manganese(II)], [MnBr(CHNO)(CHOH)] ().

Structures of substituted pyridine -oxide with manganese(II) acetate.

Manganese(II) acetate coordination polymers have been prepared with three derivatives of pyridine -oxide. The compounds are -poly[manganese(II)-μ-acetato-di-μ-acetato-[aqua-manganese(II)]-μ-acetato-μ-(pyridine -oxide)-manganese(II)-μ-acetato-μ-acetato-μ-(pyridine -oxide)-[aqua-manganese(II)]-di-μ-acetato], [Mn(CHCOO)(CHNO)(HO)] , (), -poly[[manganese(II)]-μ-acetato-μ-acetato-μ-(2-methyl-pyridine -oxide)-[aqua-manganese(II)]-di-μ-acetato-manganese(II)-di-μ-acetato-μ-acetato-[aqua-manganese(II)]-μ-acetato-μ-(2-methyl-pyridine -oxide)], [Mn(CHCOO)(CHNO)(HO)] , (), and -poly[[manganese(II)-di-μ-acetato-μ-(4-methyl-pyridine -oxide)] monohydrate], {[Mn(CHCOO)(CHNO)]·HO} , (). Compounds () and () both have three unique Mn atoms; in both compounds two of them sit on a crystallographic inversion center while the third is on a general position.

Manganese(II) chloride complexes with pyridine -oxide (PNO) derivatives and their solid-state structures.

Three manganese(II) -oxide complexes have been synthesized from the reaction of manganese(II) chloride with either pyridine -oxide (PNO), 2-methyl-pyridine -oxide (2MePNO) or 3-methyl-pyridine -oxide (3MePNO). The compounds were synthesized from methano-lic solutions of MnCl·4HO and the respective -oxide, and subsequently characterized structurally by single-crystal X-ray diffraction. The compounds are -poly[[aqua-chlorido-manganese(II)]-di-μ-chlorido-[aqua-chlorido-manganese(II)]-bis-(μ-pyridine -oxide)], [MnCl(CHNO)(HO)] or [MnCl(PNO)(HO)] (), -poly[[aqua-chlorido-man-gan-ese(II)]-di-μ-chlorido-[aqua-chlorido-manganese(II)]-bis-(μ-2-methyl-pyridine -oxide)], [MnCl(CHNO)(HO)] or [MnCl(2MePNO)(HO)] (), and bis-(μ-3-methyl-pyridine -oxide)bis-[di-aqua-dichlorido-manganese(II)], [MnCl(CHNO)(HO)] or [MnCl(3MePNO)(HO)] ().