Country ownership as a guiding principle for IA2030: A case study of the measles and rubella elimination programs in Nepal and Nigeria.

Country-owned, as opposed to donor-driven, is a principle within the development sector that recognizes the centrality of countries' leadership, systems, and resources in executing programs and achieving sustainable development. In alignment with this notion, the Immunization Agenda 2030 was developed with country ownership as one of four core principles of the ambitious ten-year plan. This means that the success of immunization programs, including those with eradication and elimination goals such as polio, measles, and rubella, and those with broader equity goals to "leave no one behind" on immunization, would be largely driven by country systems.

Global silicate weathering flux overestimated because of sediment-water cation exchange.

Rivers carry the dissolved and solid products of silicate mineral weathering, a process that removes [Formula: see text] from the atmosphere and provides a key negative climate feedback over geological timescales. Here we show that, in some river systems, a reactive exchange pool on river suspended particulate matter, bonded weakly to mineral surfaces, increases the mobile cation flux by 50%. The chemistry of both river waters and the exchange pool demonstrates exchange equilibrium, confirmed by Sr isotopes.

A Novel Element Achieves the Same Solution as an Ancestral Element During Thiamine Starvation in .

Regulatory networks often converge on very similar sequences to drive transcriptional programs due to constraints on what transcription factors are present. To determine the role of constraint loss on element evolution, we examined the recent appearance of a thiamine starvation regulated promoter in This species lacks the ancestral transcription factor Thi2, but still has the transcription factor Pdc2, which regulates thiamine starvation genes, allowing us to determine the effect of constraint change on a new promoter. We identified two different elements in - one present in the evolutionarily recent gene called , and the other element present in the other thiamine (THI) regulated genes.

A simulator study of the effects of singing on driving performance.

This study aimed to investigate how singing while driving affects driver performance. Twenty-one participants completed three trials of a simulated drive concurrently while performing a peripheral detection task (PDT); each trial was conducted either without music, with participants listening to music, or with participants singing along to music. It was hypothesised that driving performance and PDT response times would be impaired, and that driver subjective workload ratings would be higher, when participants were singing to music compared to when there was no music or when participants were listening to music.