Publications by authors named "Genevieve Guaydier-Souquieres"
Objective: To develop a cost-effective strategy for improving osteoporosis management in patients admitted to an orthopedic surgery department for low-energy fractures.
Methods: From November 2003 to July 2004, all patients over 50 years admitted to the orthopedics department of the Caen Teaching Hospital (France) for low-energy fractures were identified and evaluated by rheumatology department physicians in the same hospital.
Results: During the study period, 313 patients were identified, 257 women (mean age, 79.
Two single-nucleotide polymorphisms in the human vitamin D receptor promoter change protein-DNA complex formation and are associated with height and vitamin D status in adolescent girls.
Hum Mol Genet
November 2005
Numerous association studies have dealt with single-nucleotide polymorphisms (SNPs) in coding and intronic regions of the human vitamin D receptor (hVDR) gene. We have hypothesized that phenotypic traits may also be associated with variations in VDR expression due to the presence of SNPs in promoter regions. In this work, we have studied two SNPs located 1521 bp (G/C) and 1012 bp (A/G) upstream of the transcriptional start site of the main human VDR gene promoter.
View Article and Find Full Text PDFThe aim of the project was to assess the relationship between zinc status and bone mineralisation in pre-menarcheal adolescent girls. One hundred and thirty-nine healthy pre-menarcheal girls (Tanner pubic hair stage < or = 4), aged 12.4 +/- 1.
View Article and Find Full Text PDFObjectives: The WHO definition of osteoporosis is based on T-scores, which are calculated from mean bone mineral density values in reference populations composed of young adults. The definition of this reference population is a key-point.
Methods: We compared lumbar spine T-scores in three reference populations of young adults, one from the US and two from France.