Publications by authors named "Genevieve Giroux"
The production of influenza vaccines in plants is achieved through transient expression of viral hemagglutinins (HAs), a process mediated by the bacterial vector Agrobacterium tumefaciens. HA proteins are then produced and matured through the secretory pathway of plant cells, before being trafficked to the plasma membrane where they induce formation of virus-like particles (VLPs). Production of VLPs unavoidably impacts plant cells, as do viral suppressors of RNA silencing (VSRs) that are co-expressed to increase recombinant protein yields.
View Article and Find Full Text PDFArticle Synopsis
- The World Health Organization's global plan aims to eradicate hepatitis C by 2030 through the use of direct-acting antiviral drugs, emphasizing the need to identify those with the disease, particularly in sub-Saharan Africa (SSA).
- A study was conducted in Uganda and the Democratic Republic of Congo to assess HCV prevalence, explore detection strategies, and analyze the virus's genetic diversity, revealing several unique strains including new unassigned g7 types.
- Findings showed significant variation in serological assay specificity and identified polymorphisms in the strains related to resistance against existing antiviral treatments, highlighting the critical need for clinical trials in SSA to better understand treatment responses.
Background: The human immunodeficiency virus type 1 (HIV-1) pandemic was ignited in Léopoldville (now known as Kinshasa), in the former Belgian Congo. Factors that jump-started its early expansion remain unclear. Nonlethal hepatitis C virus (HCV) and human T-cell lymphotropic virus (HTLV-1) can be used to investigate past iatrogenic transmission.
View Article and Find Full Text PDFAmyloid plaques, the hallmark of Alzheimer's disease (AD), contain fibrillar β-amyloid (Aβ) 1-40 and 1-42 peptides. Herpes simplex virus 1 (HSV-1) has been implicated as a risk factor for AD and found to co-localize within amyloid plaques. Aβ 1-40 and Aβ 1-42 display anti-bacterial, anti-yeast and anti-viral activities.
View Article and Find Full Text PDFBackground: The spectrum of bacteria associated with bacterial vaginosis (BV) has recently expanded through taxonomic changes and the use of molecular methods. These methods have yet to be used in large-scale epidemiological studies in Africa where BV is highly prevalent.
Methods: An analysis of samples obtained during a clinical trial of the management of vaginal discharge in four West African countries.