Idiopathic adolescent scoliosis and obesity: prevalence study.

Purpose: Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that affects 5% of the population. This pathology has multiple known etiological factors such as family predisposition, female gender, low body mass index, decrease in lean and fat masses. However, recent studies suggest that ciliary dysfunction could be the origin of certain types of obesity and AIS.

Total sleep deprivation alters endothelial function in rats: a nonsympathetic mechanism.

Study Objectives: Sleep loss is suspected to induce endothelial dysfunction, a key factor in cardiovascular risk. We examined whether sympathetic activity is involved in the endothelial dysfunction caused by total sleep deprivation (TSD).

Design: TWO GROUPS: TSD (24-h wakefulness), using slowly rotating wheels, and wheel control (WC).

Effect of acute sleep deprivation on vascular function in healthy subjects.

Sleep disorders are associated with inflammation and sympathetic activation, which are suspected to induce endothelial dysfunction, a key factor in the increased risk of cardiovascular disease. Less is known about the early effects of acute sleep deprivation on vascular function. We evaluated microvascular reactivity and biological markers of endothelial activation during continuous 40 h of total sleep deprivation (TSD) in 12 healthy men (29 +/- 3 yr).

Prediction of performance level during a cognitive task from ongoing EEG oscillatory activities.

Objective: Tracking the level of performance in cognitive tasks may be useful in environments, such as aircraft, in which the awareness of the pilots is critical for security. In this paper, the usefulness of EEG for the prediction of performance is investigated.

Methods: We present a new methodology that combines various ongoing EEG measurements to predict performance level during a cognitive task.

Psychostimulants and G tolerance in rhesus monkeys: effects of oral modafinil and injected caffeine.

Introduction: Caffeine and modafinil are psychostimulants that may be taken by fighter aircraft pilots to reduce fatigue. Fighter pilots are subjected to high positive G loads that reduce cerebral blood flow and consequently may induce G-LOC. The aim of the experiment was to determine whether these drugs may reduce tolerance to G stress.

Electroencephalography (EEG) and somatosensory evoked potentials (SEP) to prevent cerebral ischaemia in the operating room.

We review the principal aspects of EEG and SEP to detect and prevent cerebral ischaemia in the operating room during interventions at risk. EEG and SEP are variables that indirectly reflect cerebral blood flow (CBF) provided that anaesthetic regimen, body temperature, and arterial blood pressure of the patient are stable. When CBF decreases and reaches the functional threshold, slowing and/or attenuation of EEG occurs while the amplitude and the latency of cortical SEP are, respectively decreased and lengthened.

Cerebral hemodynamics and brain oxygen changes related to gravity-induced loss of consciousness in rhesus monkeys.

The aim of the present experiment was to study the influence of +Gz acceleration (head-to-foot inertial forces) onset on cerebral oxygenation changes (cerebral oxy- and deoxy-hemoglobin) and cerebral blood volume (CBV) in order to evaluate the role of cerebral hypoxemia and ischemia in the appearance of +Gz-induced loss of consciousness (G-LOC). We used five rhesus monkeys which were equipped with near infrared spectroscopy optodes fixed onto the parietooccipital cranial bone. G-LOC (isoelectric electrocorticogram) was detected with silver balls electrodes in contact with the dura matter.