Publications by authors named "Genevieve Edobor"
Int J Mol Sci
August 2024
Article Synopsis
- Elastin is crucial for skin elasticity and decreases with age, making it a target for anti-aging products.
- RiboScreen technology was used to find ribosomal proteins that enhance the production of tropoelastin, identifying ribosomal protein L40 (eL40) as a key regulator.
- A small molecule that activates eL40 was discovered, leading to increased levels of tropoelastin in cells, suggesting potential applications in skincare and cardiovascular health.
Article Synopsis
- Severe junctional epidermolysis bullosa is a rare genetic skin disease mostly caused by harmful mutations in the LAMB3 gene, which is essential for skin structure.
- Current treatments using translational readthrough-inducing drugs are limited by toxicity, while ribosome editing offers a more targeted approach.
- This study found that repurposing the drugs artesunate and atazanavir, alongside ribosomal protein L35, significantly increases the production of the full-length LAMB3 protein in affected cells, suggesting a promising therapeutic option for the disease.
