A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin.

Objective: To compare the efficacy and safety of recombinant human FSH (r-hFSH) and hCG treatment for male hypogonadotropic hypogonadism (HH) in different populations and to identify characteristics predictive of spermatogenesis.

Design: A combined analysis of data from four clinical trials.

Setting: Phase III, open-label, noncomparative studies with similar designs conducted in Australia, Europe, Japan, and the United States.

Relationship of baseline ovarian volume to ovarian response in World Health Organization II anovulatory patients who underwent ovulation induction with gonadotropins.

Objective: To assess whether ovarian volume of World Health Organization II anovulatory patients in the early follicular phase predicts the response to ovulation induction with gonadotropins.

Design: Retrospective data analysis of two prospective, randomized, multicenter studies.

Setting: Clinical development unit of biotechnology company.