Cardiorespiratory Responses to Acute Intermittent Hypoxia in Humans With Chronic Spinal Cord Injury.

Brief exposure to repeated episodes of low inspired oxygen, or acute intermittent hypoxia (AIH), is a promising therapeutic modality to improve motor function after chronic, incomplete spinal cord injury (SCI). Although therapeutic AIH is under extensive investigation in persons with SCI, limited data are available concerning cardiorespiratory responses during and after AIH exposure despite implications for AIH safety and tolerability. Thus, we recorded immediate (during treatment) and enduring (up to 30 min post-treatment) cardiorespiratory responses to AIH in 19 participants with chronic SCI (>1 year post-injury; injury levels C1 to T6; American Spinal Injury Association Impairment Scale A to D; mean age = 33.

Feasibility of transcutaneous spinal direct current stimulation combined with locomotor training after spinal cord injury.

Study Design: Feasibility study, consisting of random-order, cross-over study of a single intervention session, followed by a parallel-arm study of 16 sessions.

Objectives: To investigate the feasibility of a novel combinatorial approach with simultaneous delivery of transcutaneous spinal direct current stimulation (tsDCS) and locomotor training (tsDCS + LT) after spinal cord injury, compared to sham stimulation and locomotor training (sham + LT), and examine preliminary effects on walking function.

Setting: Clinical research center in the southeastern United States.

Evaluation of a Head-Tongue Controller for Power Wheelchair Driving by People With Quadriplegia.

The head-tongue controller (HTC) is a multimodal alternative controller designed for people with quadriplegia to access complex control capabilities by combining tongue and head tracking to offer both discrete and proportional controls in a single controller. In this human study, 17 patients with quadriplegia and current users of alternative controllers were asked to perform four trials of either simple driving tasks or advanced maneuvers in a custom-designed course. Completion time and accuracy were compared between their personal alternative controller (PAC) and various combinations of driving modalities with the HTC.

Diaphragm Pacing and a Model for Respiratory Rehabilitation After Spinal Cord Injury.

Background And Purpose: Cervical spinal cord injury (CSCI) can cause severe respiratory impairment. Although mechanical ventilation (MV) is a lifesaving standard of care for these patients, it is associated with diaphragm atrophy and dysfunction. Diaphragm pacing (DP) is a strategy now used acutely to promote MV weaning and to combat the associated negative effects.