Publications by authors named "Gene Pozas"
Article Synopsis
- Cytosine methylation plays a crucial role in gene regulation and normal blood cell development, and is facilitated by DNA methyltransferases like DNMT1, DNMT3A, and DNMT3B.
- Peripheral T-cell lymphomas (PTCLs) are aggressive cancers with complex features and poor outcomes, prompting research to understand their underlying molecular mechanisms through DNA methylation and gene expression analysis.
- The study revealed significant deregulated methylation patterns in PTCLs, identified key hypo- and hypermethylated regions, and pinpointed specific genes, such as TRIP13, that could be targeted for potential therapies aimed at controlling cancer cell proliferation.
Cytosine methylation of genomic DNA contributes to the regulation of gene expression and is involved in normal development including hematopoiesis in mammals. It is catalyzed by the family of DNA methyltransferases (DNMTs) that include DNMT1, DNMT3A, and DNMT3B. Peripheral T-cell lymphomas (PTCLs) represent a diverse group of aggressive mature T-cell malignancies accounting for approximately 10-15% of non-Hodgkin lymphoma cases in the US.
View Article and Find Full Text PDF