Procedural sedation performed by pediatric critical care physicians for children undergoing daily radiation therapy is effective and safe.

Radiation therapy targets tumor tissue and requires children to lay still, often necessitating sedation. Historically anesthesiologists provided procedural sedation, but pediatric critical care physicians now regularly administer sedation outside the operating room. Procedural sedation for radiation poses unique challenges.

Race and Gender Differences in Pediatric Milestone Levels: A Multi-Institutional Study.

The Accreditation Council for Graduate Medical Education milestones assess resident competency in 6 domains. We hypothesized that disparities in milestones exist across race and gender in pediatric residencies. This is a retrospective, cross-sectional, multi-institutional study (3 pediatric residencies, 1446 scores; 316 residents).

Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions.

Objectives: Painful infectious mouth conditions such as herpangina, hand-foot-and-mouth disease, and herpetic gingivostomatitis can cause pain, dehydration, and hospitalization in young children. Treatment for these conditions is generally supportive and directed toward pain relief from ulcerative lesions, thus facilitating oral intake, and preventing dehydration. Attempts at oral therapy at home and in the emergency department are often refused and immediately spit back out.

Brief Focused Interprofessional Encounters in a Developmental-Behavioral Rotation Facilitate Pediatric Resident Experiences, Foster Interprofessional Relationships, and Improve Confidence in Mental Health and High-Risk Developmental Conditions.

Experiences with mental health (MH) and high-risk developmental conditions (HRDC) are challenging to obtain during pediatric residency. This study describes Brief Focused Interprofessional Encounters (BFIE) during a developmental-behavioral pediatric (DBP) rotation. Postgraduate year 1 (PGY1) pediatric residents recorded diagnoses of children they interacted with at each BFIE site and completed a self-assessment at the start and end of their rotation.

Coronarin D induces human oral cancer cell apoptosis though upregulate JNK1/2 signaling pathway.

The incidence of oral cancer is increasing all over the world, with rates particularly high in Southeast Asian countries, such as Taiwan. Coronarin D (CD) has been confirmed to have anti-inflammatory, anti-bacterial effects, and anti-apoptotic effects in human hepatocellular carcinoma and nasopharyngeal carcinoma. The purpose of this study is to explore whether CD has a suppression effect on oral cancer cells and the mechanisms involved.

Erianin induces cell apoptosis through ERK pathway in human nasopharyngeal carcinoma.

Background: Nasopharyngeal carcinoma (NPC) is one of the most common cancers in areas of Southeast Asia, such as Taiwan, and North Africa. The treatments of NPC, including radiotherapy and chemotherapy, were effective, but they also caused some severe side effects. Erianin, a natural product derived from Dendrobium, was proved to have anti-cancer effect in hepatoma, melanoma, non-small-cell lung carcinoma, myelogenous leukemia, breast cancer, and osteosarcoma.

The Impact of Metronomic Adjuvant Chemotherapy in Patients with Advanced Oral Cancer.

Background: This study evaluated the efficacy of tegafur-uracil for advanced oral cancer.

Methods: From January 2008 to December 2013, clinical data from 356 patients with stage III or IV oral squamous cell carcinoma who received curative surgical resection and postoperative concurrent chemoradiotherapy, treated with or without tegafur-uracil, were analyzed from a prospectively designed database. Tegafur-uracil was orally administered to 114 of the 356 patients.

Relationship Between Patient Satisfaction And Physician Characteristics.

Background: Physician care influences patient satisfaction. Inherent physician attributes may also affect scores.

Objective: To determine the relationship between physician characteristics and patient satisfaction regarding physician care and communication.

The effectiveness of school educating program for betel quid chewing: A pilot study in Papua New Guinea.

Background: To investigate the effectiveness of educating program among primary and secondary school students in Papua New Guinea, where has the highest incidence of oral cancer all over the world.

Methods: A cross-sectional school based survey was arranged in primary and secondary school in Papua New Guinea in June, 2015. A self-administrated questionnaire was administered before and after education done by health experts from Taiwan.

Response to aflibercept after frequent re-treatment with bevacizumab or ranibizumab in eyes with neovascular AMD.

Background And Objective: To evaluate the effects of switching to aflibercept in eyes with neovascular age-related macular degeneration (AMD) requiring frequent re-treatment with bevacizumab or ranibizumab.

Patients And Methods: Retrospective review of 73 eyes of 65 patients with neovascular AMD switched to aflibercept due to persistent or recurrent macular fluid after at least 1 year of intravitreal bevacizumab or ranibizumab with re-treatment at least every 6 weeks. Minimum post-switch follow-up was 6 months.

Prevalence, characteristics, and opinions of pediatric rapid response teams in the United States.

Objective: Rapid response teams (RRTs) have been proposed as patient safety initiatives for hospitalized children. The aim of this study was to determine the prevalence, characteristics, and opinions of RRTs in hospitals with PICUs in the United States.

Methods: This study was conducted as a cross-sectional survey of PICU physicians in adult and children's hospitals that care for children.

Preoperative embolization.

Preoperative embolization procedures are constantly evolving and allow the performance of, or improve the outcome of, subsequent surgical interventions. Currently, some of the more frequently performed procedures in this group are portal vein embolization (PVE) in anticipation of extended liver resection, preoperative embolization of hypervascular tumors, and chemoembolization of hepatocellular carcinoma (HCC) as a bridge to liver transplantation. The indications, technique, and results of these procedures will be reviewed.

Learning and recall in subjects at genetic risk for Alzheimer's disease.

Deficits in delayed recall of learned information may be an early marker of Alzheimer's disease (AD). The apolipoprotein E E4 allele and a positive family history (FH) are both genetic risk factors for AD. The authors cross-sectionally compared performance on the California Verbal Learning Test (CVLT) in 153 prospectively recruited normal elderly subjects (mean age 67 years, mean MMSE=28) stratified by genetic risk into four groups (E4+/FH+, E4+/FH-, E4-/FH+, E4-/FH-).