The antimicrobial potential of traditional remedies of Indigenous peoples from Canada against MRSA planktonic and biofilm bacteria in wound infection mimetic conditions.

Methicillin-resistant (MRSA) is the leading cause of wound infections, often progressing into serious invasive bloodstream infections. MRSA disproportionately affects Indigenous peoples in Canada with higher rates of skin and wound infections, an example of persistent gaps in health outcomes between Indigenous and non-Indigenous peoples precipitated by the legacy of colonialism. Conversely, Indigenous peoples have long used natural remedies for infections and other diseases; however, their knowledge was rarely considered for modern medicine.

Ligand-dependent intracellular trafficking of the G protein-coupled P2Y receptor.

Endosomal trafficking is intricately linked to G protein-coupled receptors (GPCR) fate and signaling. Extracellular uridine diphosphate (UDP) acts as a signaling molecule by selectively activating the GPCR P2Y. Despite the recent interest for this receptor in pathologies, such as gastrointestinal and neurological diseases, there is sparse information on the endosomal trafficking of P2Y receptors in response to its endogenous agonist UDP and synthetic selective agonist 5-iodo-UDP (MRS2693).

Use of Conglomerate Mixed Crystals to Deracemize a Stable Racemic-Compound-Forming System.

Deracemization extended to racemic-compound-forming systems is demonstrated. We present here the first results of an alternative for the resolution of systems that exhibit a stable racemic compound but also a closely related conglomerate-forming system. If the couples of enantiomers forming the racemic compound and the enantiomers of the stable conglomerate can syncrystallize in mirror-related partial solid solutions, it is possible to deracemize the racemic mixture of mixed crystals to access to a single handedness.

Mindfulness-based stress reduction to improve depression, pain and high patient global assessment in controlled rheumatoid arthritis.

Objective: The aim was to improve distressing patient-reported outcomes (PROs) that persisted in RA patients with clinically controlled inflammation (controlled RA).

Methods: In a pragmatic pilot study, we offered mindfulness-based stress reduction (MBSR), a group intervention, to controlled RA patients who had high (≥16) Centre for Evaluation Studies depression (CES-D) scores and/or patient general assessment of disease activity (PGA) at least 2/10 larger than evaluator general assessment (EGA) (PGA-EGA: Delta). Evaluations before, 6 and 12 months after MBSR included CES-D, PGA, modified HAQ, simple disease activity index (SDAI), anxiety (general anxiety disorder 7; GAD-7), coping strategies (coping with health injuries and problems; CHIP), sleep disturbance and pain.

Role of pressure on electronic, magnetic and structural properties at iron's Curie temperature: a DFT + DMFT study.

We use the combination of density functional theory and dynamical mean-field theory to compute the Curie temperature of the iron body-centered cubicphase and probe its pressure dependence. Our calculations reveal thatTCshows a decrease which is very weak over a domain of pressures that is much larger than the stability domain of thephase. This is consistent with the experimental results.

Near-infrared circular dichroism of the ytterbium DOTMA complex: an investigation.

The electronic structure and circular dichroism spectra of the ytterbium(III) complex [Yb(DOTMA)] are calculated using complete and restricted active space self-consistent field wavefunction methods with the spin-orbit coupling treated by the state interaction approach. The influence of the dynamical correlation effect is then included the 2nd order perturbation method. The experimental circular dichroism spectrum is well reproduced by calculations, both in terms of relative energy excitations and in terms of rotatory strength intensities.

The M de Jussieu's 'mirror of the Incas': an ecuadorian archaeological artefact in the mineralogical collection of René-Just Haüy (1743-1822).

This article reports on a historical investigation carried out on the conical object MIN000-3519 preserved in the mineralogy collections of the at Paris (France). The mineralogist René-Just Haüy (1743-1822) included this object, cut in a single pyrite (FeS) crystal, in his working collection with the references 'Sulphured iron, mirror of the Incas, of Peru, M. de Jussieu'.

Equatorial Electronic Structure in the Uranyl Ion: CsUOCl and CsUOBr.

Electric field gradient (EFG) tensors in the equatorial plane of the linear UO ion have been measured by nuclear magnetic resonance (NMR) and nuclear quadrupole resonance (NQR) experiments and computed by relativistic Kohn-Sham methods with and without environment embedding for CsUOCl and CsUOBr. This approach expands the possibilities for probing the electronic structure in uranyl complexes beyond the strongly covalent U-O bonds. The combined analyses find that one of the two largest principal EFG tensor components at the halogen sites points along the U-X bond (X = Cl, Br), and the second is parallel to the UO ion; in CsUOCl, the components are nearly equal in magnitude, whereas in CsUOBr, due to short-range bromide-cesium interactions, the equatorial component is dominant for one pair of Br sites and the axial component is larger for the second pair.

Combined Experimental/Theoretical Study on the Luminescent Properties of Homoleptic/Heteroleptic Erbium(III) Anilate-Based 2D Coordination Polymers.

The synthesis, structural and photophysical characterization, and theoretical studies on homo/heteroleptic neutral 2D-layered coordination polymers (CPs), obtained by combining the Er ion with chlorocyananilate (ClCNAn) and/or tetrafluoroterephthalate (FBDC) linkers, are herein reported. The structure of the heteroleptic Er-based CP, formulated as [Er(ClCNAn)(FBDC)(DMSO)] () is also reported. crystallizes in the triclinic 1̅ space group, and the structure consists of neutral 2D layers formed by Er ions linked through the two linkers oriented in such a way that the neighboring 2D layers are eclipsed along the axis, leading to parallelogram-like cavities.

Single-chain magnet behavior in a finite linear hexanuclear molecule.

The careful monitoring of crystallization conditions of a mixture made of a Tb building block and a substituted nitronyl-nitroxide that typically provides infinite coordination polymers (), affords a remarkably stable linear hexanuclear molecule made of six Tb ions and five NIT radicals. The are double-bridged by water molecules but calculations demonstrate that this bridge is inefficient in mediating any magnetic interaction other than a small dipolar antiferromagnetic coupling. Surprisingly the , despite being finite molecules, show a single-chain magnet (SCM) behavior.

Chiral Benzothiazole Monofluoroborate Featuring Chiroptical and Oxygen-Sensitizing Properties: Synthesis and Photophysical Studies.

Advances in personalized medicine are prompting the development of multimodal agents, that is, molecules that combine properties promoting various diagnostic and therapeutic applications. General approaches exploit chemical conjugation of therapeutic agents with contrast agents or the design of multimodal nanoplatforms. Herein, we report the design of a single molecule that exhibits potential for different diagnostic modes as well as the ability to sensitize oxygen, thus offering potential for photodynamic therapy.

A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.

The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC) stimulates the production of the pro-tumorigenic splice variant. We discovered a group of small molecules with an aminothiazole carboxamide core (GPS167, GPS192 and others) that decrease production of . While additional alternative splicing events regulated by SRSF10 are affected by GPS167/192 in HCT116 cells (e.

Size-Controlled Hapticity Switching in [Ln(C H )(C H )] Sandwiches.

Sandwich complexes of lanthanides have recently attracted a considerable amount of interest due to their applications as Single Molecule Magnet (SMM). Herein, a comprehensive series of heteroleptic lanthanide sandwich complexes ligated by the cyclononatetraenyl (Cnt) and the cyclooctatetraenyl (Cot) ligand [Ln(Cot)(Cnt)] (Ln=Tb, Dy, Er, Ho, Yb, and Lu) is reported. The coordination behavior of the Cnt ligand has been investigated along the series and shows different coordination patterns in the solid-state depending on the size of the corresponding lanthanide ion without altering its overall anisotropy.

Thiophene-Bipyridine Appended Diketopyrrolopyrrole Ligands and Platinum(II) Complexes.

Straightforward palladium(II) catalyzed direct cross-coupling reaction between decyl, ()-2-methyl-butyl, and dodecyl -substituted diketopyrrolopyrrole thiophene (DPPT), including a 3-methoxy-thiophene derivative, and 6-bromo-2,2'-bipyridine afforded a series of mono- and bis-bipyridine substituted DPPT ligands -. Complexation reactions with PtCl(DMSO) provided ortho-metalated platinum(II) complexes and , together with the N^N^O complex () resulted from the O-Me activation of the intermediary complex (). The ligand and the mononuclear complexes and have been structurally characterized by single crystal X-ray structure, evidencing the establishment of numerous intermolecular π-π interactions in the solid state.

Solid-State Near-Infrared Circularly Polarized Luminescence from Chiral Yb -Single-Molecule Magnet.

A field-induced chiral Yb Single-Molecule Magnet (SMM) displayed an unprecedented near-infrared circularly polarized luminescence (NIR-CPL) in the solid-state. The bridging bis(1,10-phenantro[5,6b])tetrathiafulvalene triad (L) allowed an efficient sensitization of the NIR F → F emission while the NIR-CPL is associated to the f-f transitions of the Yb ion bearing chiral β-diketonate derived-camphorate ancillary ligands.

The expression of P2Y receptor promotes the quality of mucus in colitic mice.

In the intestine, mucins are expressed and secreted by goblet cells and enterocytes in a constitutive manner and in response to secretagogues to form a protective mucus layer. This protective barrier is often lost in inflammatory bowel disease (IBD). Interestingly, extracellular nucleotides, through P2Y receptors, were identified as mucin secretagogues in mucinous epithelia.

A new class of Dy-SIMs associated with a guanidine-based ligand.

A family of four mononuclear DyIII complexes of the guanidine-based ligand L [L = tris(2-hydroxybenzylidene)triaminoguanidine] with formulas [DyLCl2(DMF)2]·DMF·CH3OH (1), [DyL2(CH3OH)2]Br·H2O·3CH3OH (2), [DyL2(H2O)2]SCN·3H2O·CH3OH (3) and [DyL2(CH3OH)2]SCN·CH3CN·CH3OH (4) were successfully prepared by varying reaction conditions. Complex 1 is seven-coordinate, with three N2O from ligand L along with two equatorially trapped DMF molecules and two axial Cl- anions, adopting pentagonal bipyramidal D5h symmetry. Complexes 2-4 have somewhat similar structures with six donor N4O2 sites from two ligands and two O from corresponding solvent molecules, featuring a N4O4 octa-coordinate environment with triangular dodecahedron D2d symmetry.

Bis-cyclooctatetraenyl Thulium(II): Highly Reducing Lanthanide Sandwich Single Molecule Magnets.

Divalent lanthanide organometallics are well-known highly reducing compounds usually used for single electron transfer reactivity and small molecule activation. Thus, their very reactive nature prevented for many years the study of their physical properties, such as magnetic studies on a reliable basis. In this article, the access to rare organometallic sandwich compounds of Tm with the cyclooctatetraenyl (Cot) ligand impacts on the use of divalent organolanthanide compounds as an additional strategy for the design of performing Single Molecule Magnets (SMM).

Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factor.

Bone mineralization is an orchestrated process by which mineral crystals are deposited by osteoblasts; however, the detailed mechanisms remain to be elucidated. The presence of P2X7 receptor (P2X7R) in immature and mature bone cells is well established, but contrasting evidence on its role in osteogenic differentiation and deposition of calcified bone matrix remains. To clarify these controversies in the present study, we investigated P2X7R participation in bone maturation.

The P2Y receptor signals through Gα /Ca /PKCα and Gα /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration.

Cell migration is a ubiquitous process necessary to maintain and restore tissue functions. However, in cancer, cell migration leads to metastasis development and thus worsens the prognosis. Although the mechanism of cell migration is well understood, the identification of new targets modulating cell migration and deciphering their signaling events could lead to new therapies to restore tissue functions in diseases, such as inflammatory bowel disease, or to block metastatic development in different forms of cancer.

The expression of the P2Y receptor is regulated at the transcriptional level by p53.

Inflammatory bowel disease (IBD) is a risk factor for the development of colorectal cancer (CRC) for which mutation to p53 is an early event leading to dysplasia. Interestingly, P2RY6 mRNA increases in both pathologies. In this study, we investigated if p53 and p53 mutant, commonly found in CRC and IBD, were involved in the transcriptional regulation of P2RY6.

Redox-Modulations of Photophysical and Single-molecule Magnet Properties in Ytterbium Complexes Involving Extended-TTF Triads.

The reaction between the 2,2'-benzene-1,4-diylbis(6-hydroxy-4,7-di--butyl-1,3-benzodithiol-2-ylium-5-olate triad () and the metallo-precursor [Yb(hfac)]2HO led to the formation of a dinuclear coordination complex of formula [Yb(hfac)()]0.5CHCl (). After chemical oxidation of in 2,2'-cyclohexa-2,5-diene-1,4-diylidenebis(4,7-di--butyl-1,3-benzodithiole-5,6-dione (), the latter triad reacted with the [Yb(hfac)]2HO precursor to give the dinuclear complex of formula [Yb(hfac)()] ().

Luminescence-Driven Electronic Structure Determination in a Textbook Dimeric Dy -Based Single-Molecule Magnet.

A textbook dysprosium dinuclear complex based on acetylacetone ligands, [Dy (acac) (μ -acac) (H O) ], has been synthesized and fully characterized. This simple dimeric lanthanide complex shows well-resolved solid-state luminescence and behaves as a single-molecule magnet under zero DC field. A seminal crystal-field approach is used to marry both magnetism and luminescence in the frame of an energetic picture.

Hysteresis Photomodulation via Single-Crystal-to-Single-Crystal Isomerization of a Photochromic Chain of Dysprosium Single-Molecule Magnets.

A one-dimensional coordination solid is synthesized by reaction of a bispyridyl dithienylethene (DTE) photochromic unit with the highly anisotropic dysprosium-based single-molecule magnet [Dy(Tp)F(pyridine)]PF. Slow magnetic relaxation characteristics are retained in the chain compound , and photoisomerization of the bridging DTE ligand induces a single-crystal-to-single-crystal transformation that can be monitored using photocrystallography. Notably, the resulting chain compound exhibits faster low-temperature relaxation than that of , which is apparent in magnetic hysteresis data collected for both compounds as high as 4 K.

Chiral Supramolecular Nanotubes of Single-Chain Magnets.

We report a single-chain magnet (SCM) made of a terbium(III) building block and a nitronyl-nitroxide radical (NIT) functionalized with an aliphatic chain. This substitution is targeted to induce a long-range distortion of the polymeric chain and accordingly it gives rise to chains that are curled with almost 20 nm helical pitch. They self-organize as a chiral tubular superstructure made of 11 chains wound around each other.