Publications by authors named "Gen-Hua Zhao"
Article Synopsis
- Psoralen and isopsoralen are two important isomers found in scurfpea fruit, and a new UHPLC-MS/MS method was developed to study their tissue distribution after being processed with salt.
- The study found that salt-processing significantly increased the area under the curve (AUC) for these compounds in various tissues, especially in the heart, ovary, and testes, compared to the crude form.
- Results indicate that salt-processing enhances the distribution of psoralen and isopsoralen to generative organs more than to the heart and spleen, highlighting its potential effects on reproductive health.
Estrogen replacement therapy (ERT) is utilized as a major regime for treatment of postmenopausal osteoporosis at present. However, long-term supplement of estrogen may cause uterine hyperplasia and hypertension leading to a high risk of endometrial cancer and breast cancer. Psoralea corylifolia L.
View Article and Find Full Text PDFA sensitive, specific and rapid ultra-high-pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method has been developed to investigate pharmacokinetic properties of psoralen and isopsoralen, two compounds isolated from raw/salt-processed fruit of Psoralea corylifolia L. UHPLC-MS/MS was used with positive ion electrospray. The mobile phase was composed of acetonitrile and 0.
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