Publications by authors named "Gen Qi"
It is a challenge to invigorate tumor-infiltrating lymphocytes without causing immune-related adverse events, which also stands as a primary factor contributing to resistance against cancer immunotherapies. Interleukin (IL)-15 can potently promote expansion and activation of T cells, but its clinical use has been limited by dose-limiting toxicities. In this study, we develop a tumor-conditional IL-15 (pro-IL-15), which masks IL-15 with steric hindrance caused by Fc fragment and IL-15Rα-sushi domain.
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- PRRSV is a major virus affecting pigs, causing severe reproductive issues and high mortality among piglets, leading to significant economic losses globally.
- A specific strain from Inner Mongolia, CHNMGKL1-2304, was isolated and found to be moderately virulent, exhibiting symptoms like fever and weight loss in infected piglets without causing death.
- The study characterized the strain and confirmed its unique pathogenic characteristics, providing valuable information for future research and understanding the virus's impact.