Omega-3 PUFAs improve cognitive function in heat-stressed mice by enhancing autophagy inhibition of the phosphorylation of the PI3K-Akt-mTOR pathway.

The adverse effects of elevated temperatures on human health are becoming progressively severe. This research established a mouse model of cognitive dysfunction induced by heat stress to examine the impact of omega-3 PUFAs on the cognitive capabilities of heat-stressed mice. The study also aimed to elucidate the role and potential mechanisms of autophagy regulation in cognitive enhancement through omega-3 PUFAs interventions.

Research Advances on the Role of Lipids in the Life Cycle of Human Coronaviruses.

Coronaviruses (CoVs) are emerging pathogens with a significant potential to cause life-threatening harm to human health. Since the beginning of the 21st century, three highly pathogenic and transmissible human CoVs have emerged, triggering epidemics and posing major threats to global public health. CoVs are enveloped viruses encased in a lipid bilayer.

Direct detection system for independent triplet-sideband signals based on a single photodiode.

This paper proposes a novel, to the best of our knowledge, independent triplet-single-sideband (triplet-SSB) transmission system scheme aimed at increasing channel capacity and improving spectrum efficiency. The conventional independent multiband transmission systems are limited by their complexity and high computational requirements, which hinder the improvement of spectrum efficiency and channel capacity. To address these challenges, this scheme uses three independent signals, modulated by an in-phase/quadrature (I/Q) modulator, and transmits them over a 5-km standard single-mode fiber (SSMF).

Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the seventh member of the coronavirus family that can infect humans. Recently, more contagious and pathogenic variants of SARS-CoV-2 have been continuously emerging. Clinical candidates with high efficacy and ready availability are still in urgent need.

[The effect of rosuvastatin therapy on CCR2 expression in mononuclear cells and its upstream pathway].

Objective: To investigate the effect of rosuvastatin therapy on C-C chemokine receptor(CCR2)expression in mononuclear cells in patients with carotid atherosclerosis and explore the possible upstream mechanism.

Methods: Twenty patients without previous statin treatment were enrolled. Rosuvastatin were given 5 to 20 mg/day for 3 months.

Identification of leukemia-associated antigens in chronic myeloid leukemia by proteomic analysis.

The immune system plays an important role in the treatment of chronic myeloid leukemia (CML). Identification of leukemia-associated antigens (LAAs) eliciting an immune response in patients is a prerequisite for specific immunotherapy of CML. To identify new LAAs in CML, We utilized a novel approach based serology and proteomics technologies.

[Development of a freezing drier for lyophilization of biomaterials].

To observe and assess the performance and effect of our self-made FD-1 freezing drier on biomaterials. R502 compressor and R502 refrigerating agent were adopted. In the experiment, FD-1 lyophilized collagen sponge, strain and defibrinogenase.