Exploring FAM13A-N-Myc interactions to uncover potential targets in MYCN-amplified neuroblastoma: a study of protein interactions and molecular dynamics simulations.

Neuroblastoma (NB), a common infantile neuroendocrine tumor, presents a substantial therapeutic challenge when MYCN is amplified. Given that the protein structure of N-Myc is disordered, we utilized Alphafold for prediction and GROMACS for optimization of the N-Myc structure, thereby improving the reliability of the predicted structure. The publicly available datasets GSE49710 and GSE73517 were adopted, which contain the transcriptome data of clinical samples from 598 NB patients.

Mitigating the vertical migration and leaching risks of antibiotic resistance genes through insect fertilizer application.

The leaching and vertical migration risks of antibiotic resistance genes (ARGs) from fertilized soil to groundwater poses a significant threat to ecological and public safety. Insect fertilizer, particularly black soldier fly organic fertilizer (BOF), renowned for its minimal antibiotic resistance, emerge as a promising alternative for sustainable agricultural fertilization. This study employs soil-column leaching experiments to evaluate the impact of BOF on the leaching behavior of ARGs.

Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study.

Background: Immunosenescence, the gradual deterioration of the immune system, is critical for aging-related diseases. However, the lack of detailed population-level immune data has limited our understanding, underscoring the need for innovative analytical approaches. The Health and Retirement Study (HRS) in the United States provides a unique opportunity to examine T and B lymphocyte subsets using compositional data analysis and dimension reduction techniques.

Effects of Exercise on Depression and Anxiety in Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Numerous studies have investigated the effects of exercise on depression and anxiety in breast cancer survivors, yet the results remain inconsistent. The aim of this study was to investigate the effects of exercise on depression and anxiety in breast cancer survivors and to ascertain the optimal exercise regimen for this patient population.

Methods: A comprehensive search was conducted across Embase, PubMed, the Cochrane Library, Web of Science, and Scopus until 28 October 2023.

Analysis of fungal microbiota diversity and potential pathogenic fungi in oral secretions and gut feces of captive giant pandas.

Background: Maintaining good oral and gut health is essential for the wellbeing of animals, and fungi are key components of the oral and gut microbiota. This study aims to explore the diversity and seasonal dynamics of oral and gut fungal communities in captive giant pandas, with a focus on their potential functional roles in health and digestion.

Methods: In the study, we collected saliva and fecal samples from 60 captive giant pandas were collected in different seasons, oral and gut fungi were analyzed using internal transcribed spacer (ITS) amplicon sequencing.

Clinical utility of nanopore-targeted sequencing for diagnosing and treating pulmonary infectious diseases from bronchoalveolar lavage fluid.

Background: Conventional microbial testing (CMTs) for infectious pathogens faces challenges in rapid and comprehensive detection. Nanopore-targeted sequencing (NTS) is a novel approach for rapid identification of pathogens; however, clinical experience with the application of NTS is limited.

Methods: We evaluated the diagnostic value of NTS for detecting microbes in bronchoalveolar lavage fluid samples in patients with pulmonary infectious disease (PID, 137 cases), non-pulmonary infectious disease (NPID, 32 cases), or with an unknown etiology (11 cases).

Polypropylene microplastic exposure modulates multiple metabolic pathways in tobacco leaves, impacting lignin biosynthesis.

The adverse effects of microplastics (MPs) and nanoplastics (NPs) on plant growth have gained significant attention. However, the response of tobacco plants to polypropylene microplastics (PP-MPs) remains poorly understood. To address this, a microcosm experiment was conducted in which tobacco seedlings were exposed to PP-MPs at varying concentrations (100 and 1000 mg/kg) and particle sizes (20 nm and 100 µm) for 48 days in red soil.

Non-Invasive Assessment of Dynamic Cerebral Blood Flow Using Near-Field Coupling and Synchronized Electrocardiography.

Dynamic assessment of cerebral blood flow (CBF) is crucial for the prevention and treatment of cerebrovascular diseases. Near-field coupling (NFC), due to its non-invasive and continuous advantages, holds significant promise in the dynamic assessment of CBF compared to traditional detection methods. However, challenges related to individual differences persist.

Effects of exercise on pulse wave velocity in hypertensive and prehypertensive patients: a systematic review and meta-analysis of randomized controlled trials.

Background: This study aimed to examine the effects of exercise on pulse wave velocity (PWV) in hypertensive and prehypertensive patients.

Methods: A comprehensive search was performed in PubMed, Cochrane, Embase, Scopus, and Web of Science, covering data up to August 31, 2023. A meta-analysis was conducted to determine the weighted mean difference (WMD) and 95% confidence interval for the effects of exercise on PWV in hypertensive and prehypertensive patients.

Effects of Exercise on Post-Stroke Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Numerous studies have investigated the effects of exercise on post-stroke depression (PSD), yet the findings remain inconclusive. This study aims to evaluate the impact of exercise on depressive symptoms in stroke patients and to identify the most effective exercise protocols for this population. A systematic review of the Embase, PubMed, Cochrane Library, Web of Science, and Scopus databases was conducted, with a search cutoff date of 13 September 2024.

Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatment.

Background: The emergence of targeted therapies and immunotherapy has broadened treatment options for patients with pancreatic ductal adenocarcinoma (PDAC). Despite this, traditional drug selection, predominantly relies on tumor markers and clinical staging, has underutilized these drugs due to ignoring patient genomic diversity. Patient-derived organoids (PDOs) and corresponding patient-derived organoid xenograft (PDOX) models offer a way to better understand and address this.

The impact of indocyanine green on partial nephrectomy perioperative outcomes.

We conducted a retrospective analysis of the impact of indocyanine green (ICG) on perioperative outcomes in partial nephrectomy. The utility of ICG in partial nephrectomy remains unclear. We performed a retrospective cohort study of all patients at a single institution who underwent laparoscopic or robotic partial nephrectomy in 2014-2019.

Porcine epidemic diarrhea virus induces mitophagy to inhibit the apoptosis and activation of JAK/STAT1 pathway.

Porcine epidemic diarrhea virus (PEDV) infection leads to immunosuppression and clinical symptoms in piglets, including vomiting, watery diarrhea, dehydration, and even death. Mitophagy sustains mitochondrial energy homeostasis and quality through the removal of damaged mitochondria. However, PEDV disrupts mitochondrial homeostasis, which affects cellular energy supply and reproduction.

Analysis of respiratory RNA virus detection in the laboratory of a teaching hospital in Shanghai from 2017 to 2023.

Objective: The aim of this study was to analyze the detection and epidemiological characteristics of common influenza viruses (IVA/IVB) and respiratory syncytial virus (RSV) in a teaching hospital in Shanghai from 2017 to 2023, and to investigate the impact of the COVID-19 epidemic on the transmission and detection rates of these viruses.

Methods: Retrospective analysis of IVA/IVB and RSV cases detected in hospitals from 2017 to 2023. Data was categorized into pre, during and post outbreaks based on the timing of the COVID-19 outbreak and further subdivided by season and age group.

Comparative safety analysis of Hedgehog inhibitor preparations: insights from the FAERS database.

Background: Vismodegib and sonidegib are currently the only Hedgehog inhibitors (HHIs) approved by the U.S. Food and Drug Administration (FDA) for the treatment of locally advanced BCC (laBCC).

ProG-SOL: Predicting Protein Solubility Using Protein Embeddings and Dual-Graph Convolutional Networks.

Solubility is a key biophysical property of proteins and is essential for evaluating the effectiveness of proteins in biochemical engineering. In recent years, the prediction method of protein solubility has received extensive attention in the protein engineering research community. Many methods have been developed to predict protein solubility, but the generalization performance of existing prediction methods on independent test sets must be improved.

Study and application on the size effect and end effect of red sandstone mechanical properties.

Based on the size effect, end effect, and burst tendency of rocks, this paper designs and conducts a series of uniaxial compression laboratory experiments and numerical simulation experiments to explore the influence of these factors on the mechanical properties of rocks. Dense, hard, and brittle red sandstone was used in the experiments, and specimens with different heights, cross-sectional areas, and cubic volumes were prepared. By measuring stress-strain curves, uniaxial compressive strength, and other physical and mechanical parameters, the effects of size effect on rock strength and failure modes were analyzed.

Chiral Pt(II)-V(V) Bimetallic Cages and Guest-Induced Allosteric Regulation of Catalytic Asymmetric Sulfoxidation.

Flexible metal-organic cages can provide confined active metal sites and show promise in mimicking metalloenzymes. In this study, we synthesized two flexible chiral bimetallic coordination cages, [(PEt)Pt(,,-)] and its enantiomer, through the self-assembly of platinum(II) precursors with enantiopure tripodal vanadium(V) complexes bearing pendant pyridyl groups (). The cages show guest binding with chiral camphorsulfonate anions, concomitant with changes in the cage conformation.

Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets.

The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti-inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune mechanisms in HF.

Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring.

Numerous risk factors for oesophageal cancer are linked to lifestyle habits, but the role of early-life factors in its incidence and mortality is unclear. Using UK Biobank data, we explore the association among breastfeeding, maternal smoking, smoking in offspring, and oesophageal cancer risk in adult offspring via multivariable Cox regression. Here, we show that being breastfed, compared with not being breastfed, is associated with a lower risk of oesophageal cancer incidence (HR: 0.

Digital channel-enabled distributed force decoding via small datasets for hand-centric interactions.

Tactile interfaces are essential for enhancing human-machine interactions, yet achieving large-scale, precise distributed force sensing remains challenging due to signal coupling and inefficient data processing. Inspired by the spiral structure of and the processing principles of neuronal systems, this study presents a digital channel-enabled distributed force decoding strategy, resulting in a phygital tactile sensing system named PhyTac. This innovative system effectively prevents marker overlap and accurately identifies multipoint stimuli up to 368 regions from coupled signals.

Artificial intelligence in drug development.

Drug development is a complex and time-consuming endeavor that traditionally relies on the experience of drug developers and trial-and-error experimentation. The advent of artificial intelligence (AI) technologies, particularly emerging large language models and generative AI, is poised to redefine this paradigm. The integration of AI-driven methodologies into the drug development pipeline has already heralded subtle yet meaningful enhancements in both the efficiency and effectiveness of this process.

A carrier-free ultrasound-responsive polyphenol nanonetworks with enhanced sonodynamic-immunotherapy for synergistic therapy of breast cancer.

Sonodynamic therapy (SDT) is an efficient non-invasive strategy for treating breast cancer. However, the therapeutic efficacy of SDT is greatly limited by various defense mechanisms in the tumor microenvironment, particularly the overexpression of B-cell lymphoma-2 (Bcl-2). In this study, based on drug self-delivery systems, a carrier-free ultrasound-responsive polyphenol nanonetwork (GTC) was developed to enhance SDT by inhibiting Bcl-2.

Moisture-driven carbonation kinetics for ultrafast CO mineralization.

CO mineralization, a process where CO reacts with minerals to form stable carbonates, presents a sustainable approach for CO sequestration and mitigation of global warming. While the crucial role of water in regulating CO mineralization efficiency is widely acknowledged, a comprehensive understanding of the underlying mechanisms remains elusive. This study employs a combined experimental and atomistic simulation approach to elucidate the intricate mechanisms governing moisture-driven carbonation kinetics of calcium-bearing minerals.