Publications by authors named "Gen Feng Zhu"
Article Synopsis
- Breast cancer is a major threat to women's health, and the COP9 complex, particularly the CSN4 subunit, is linked to tumor development.
- Researchers created a CSN4-knockdown cell line from the breast cancer cell line MDA-MB-231, finding that knocking down CSN4 reduced cell proliferation and increased apoptosis.
- The study reveals that CSN4 influences breast cancer cell growth and death by regulating genes like CDK6 and Caspase3, enhancing our understanding of cancer biology.
[New polymorphic microsatellite loci identified using genomic resource for Schistosoma japonicum].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
April 2008
Objective: To identify new microsatellite loci from genome sequence database for the study of polymorphism of Schistosoma japonicum.
Methods: Schistosoma japonicum isolates were obtained from seven endemic sites in China: Tongling and Guichi counties of Anhui Province, Duchang county of Jiangxi Province, Changde and Yueyang Cities of Hunan Province, Shashi City of Hubei Province, Xichang City of Sichuan Province. In order to study the genetic variance, genomic DNAs of 96 individual adult worms were screened against 17 new Schistosoma japonicum microsatellites and the raw data were analyzed by GenMapper 4.
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur.
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- Retinoic acids (RAs) affect physiological functions via retinoic acid receptors (RARs) and retinoid X receptors (RXRs), with RAR(alpha) being a key focus due to its involvement in acute promyelocytic leukemia (APL) through chromosomal translocations.
- In APL, RAR(alpha) is commonly fused with the PML gene from the t(15;17) translocation, leading to the formation of three transcript types: long (L), short (S), and variant (V), with the V-type having distinct features and unclear formation processes.
- Analysis of the RAR(alpha) gene revealed that "spacer" sequences found in V-type transcripts are located in