Erring on the side of caution: Two failures to replicate the derring effect.

It has been claimed that deliberately making errors while studying, even when the correct answers are provided, can enhance memory for the correct answers, a phenomenon termed the derring effect. Such deliberate erring has been shown to outperform other learning techniques, including copying and underlining, elaborative studying with concept mapping, and synonym generation. To date, however, the derring effect has only been demonstrated by a single group of researchers and in a single population of participants.

Anesthetic Management of a Patient With Distal Acquired Demyelinating Symmetric (DADS) Neuropathy Under General Anesthesia.

Distal acquired demyelinating symmetric (DADS) neuropathy is a form of chronic inflammatory demyelinating polyradiculopathy (CIDP) which can present many risks to patients undergoing anesthesia. There are currently no specific guidelines for the management of patients with any form of CIDP. This case report describes a 65-year-old male with DADS neuropathy who underwent elective total hip arthroplasty.

Pathogenic Activation of Mesenchymal Stem Cells Is Induced by the Disease Microenvironment in Systemic Sclerosis.

Objective: In systemic sclerosis (SSc), a persistent tissue repair process leads to progressive fibrosis of the skin and internal organs. The role of mesenchymal stem cells (MSCs), which characteristically initiate and regulate tissue repair, has not been fully evaluated. We undertook this study to investigate whether dividing metakaryotic MSCs are present in SSc skin and to examine whether exposure to the disease microenvironment activates MSCs and leads to transdifferentiation.

Peptide ligations accelerated by N-terminal aspartate and glutamate residues.

A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated.

Natural product-like synthetic libraries.

There is a paucity of chemical matter suitably poised for effective drug development. Improving the quality and efficiency of research early on in the drug discovery process has been a long standing objective for the drug industry and improvements to the accessibility and quality of compound screening decks might have a significant and positive impact. In the absence of specific molecular information that can be modeled and used predicatively we are far from identifying which small molecules are most relevant to emerging biological targets such as protein-protein interactions.

The effects of low- and high-glycemic index meals on time trial performance.

Purpose: The aim of this work was to determine whether the consumption of pre-exercise high- or low-glycemic index (GI) meals has a beneficial effect on time trial performance.

Methods: Eight male cyclists were provided with either a high-GI or low-GI meal, providing 1 g x kg(-1) body mass of carbohydrate, 45 min before performing a 40-km time trial on a Velotron cyclePro.

Results: Time trial performance was significantly improved in the low-GI trial (92.

Phosphate-assisted peptide ligation.

A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.

Effect of the glycaemic index of a pre-exercise meal on metabolism and cycling time trial performance.

This study investigated the effects of low or high glycaemic index (GI) foods consumed prior to a 40 km time trial (TT) on metabolism and subsequent endurance performance. Ten male cyclists consumed high GI or low GI meals, providing 1 g kg(-1) body mass of carbohydrate, 45 min prior to the TT. The TT performance was significantly (p=0.

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureus dihydrofolate reductase.

Gemmacin B: bringing diversity back into focus.

Through the synthesis of a focused library and SAR investigations, a more potent analogue of gemmacin (discovered in a previous diversity-oriented synthesis (DOS) campaign), gemmacin B, was discovered.

Diversity-oriented synthesis.

Diversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what can be achieved using the DOS approach to library generation. We describe some of the most successful strategies utilized in DOS, with special focus on our own area of interest; DOS from simple, pluripotent starting materials.

2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator.

Diastereomeric 2-methoxycyclopentyl analogues of a natural quorum sensing signaling molecule from Pseudomonas aeruginosa were synthesized and screened in pigment production assays with P. aeruginosa and Serratia strain ATCC39006.

[German version of the math anxiety questionnaire (FRA) for 6- to 9-year-old children].

Objectives: Is the FRA a reliable and valid instrument? Are there any gender differences concerning math anxiety? Are there any developmental changes in this regard in the course of the early grades?

Methods: Together with the dyscalculia test TEDI-MATH, the FRA was presented to a total of 450 children from the first to the third grade of primary school (at least 40 girls and 40 boys per semester).

Results: The total scale has an internal consistency (Cronbach's alpha) between 0.83 and 0.

Enriching chemical space with diversity-oriented synthesis.

The search for new molecular entities in drug discovery and chemical genetic programs requires the screening of high-quality collections of structurally diverse small molecules. The design and synthesis of such collections remains a major challenge to synthetic chemists. Recent strategies and results are presented in the context of the chemical space being interrogated.

Cell-cell communication in Gram-negative bacteria.

Over the last decade or so, a wealth of research has established that bacteria communicate with one another using small molecules. These signals enable the individuals in a population to coordinate their behaviour. In the case of pathogens, this behaviour may include decisions such as when to attack a host organism or form a biofilm.

Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages.

Pseudomonas aeruginosa produces the quorum sensing signalling molecule N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL). This natural product not only coordinates production of virulence factors by the bacterium, but also has immunomodulatory effects on the host organism. Immunomodulatory small molecules are valuable for immunology research and are potential therapeutics for autoimmune diseases such as rheumatoid arthritis, and immunosuppressive drugs following organ transplants.

Structure-activity relationships of Erwinia carotovora quorum sensing signaling molecules.

Production of virulence factors and secondary metabolites is regulated in the phytopathogen Erwinia carotovora by quorum sensing involving N-acylated homoserine lactone (AHL) signaling molecules. Non-hydrolyzable AHL analogues were synthesized and screened in vivo. The biological activity of each compound was correlated with its ability to bind Erwinia AHL receptor proteins (LuxR homologues) in vitro.

Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation.

The human pathogen Pseudomonas aeruginosa uses N-butyryl-L-homoserine lactone (BHL) and N-(3-oxododecanyl)-L-homoserine lactone (OdDHL) as small molecule intercellular signals in a phenomenon known as quorum sensing (QS). QS modulators are effective at attenuating P. aeruginosa virulence; therefore, they are a potential new class of antibacterial agent.

Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis.

Bromopolystyrene beads with diameters of up to 600 microm have been derivatized completely, via bromine-magnesium exchange and interception with electrophiles, to yield high quality solid-supported reagents, scavengers and solid supports for use in diversity-oriented synthesis.

Anion-directed assembly: the first fluoride-directed double helix.

The crystal structures of anion complexes of two nitroaromatic functionalised isophthalamides are reported; the structures reveal assembly around anions in the solid-state and in the case of the fluoride complex of receptor 2, the formation of a double helix.