Publications by authors named "Gemma Dawe"
Acute subdural hemorrhages are a common emergency presentation often associated with trauma. However, in the absence of significant trauma, it is important to consider alternative causes. In this case, a 58-year-old woman with trivial trauma after a sudden collapse had bilateral subdural hemorrhages on CT.
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- Diffusion-weighted imaging (DWI) is mainly used to evaluate brain tissue, especially during acute strokes.* -
- DWI's applications also cover extra-axial structures in the head and neck, providing insights into various disorders beyond just the brain.* -
- The article emphasizes the importance of thoroughly examining both intra- and extra-axial structures on DWI for a comprehensive assessment.*
Article Synopsis
- Addiction is viewed as a 'reward deficient' state, where individuals turn to substances to compensate for low reward signals, particularly involving the dysregulation of the opioid system.
- Research indicates that low levels of natural opioids are linked to a higher risk of alcohol dependence, while increased mu-opioid receptor (MOR) availability during early abstinence correlates with stronger cravings, which may inform treatment strategies.
- A study using PET scans with [C]carfentanil showed that abstinent alcohol-dependent participants had reduced opioid release after taking dexamphetamine in certain brain regions, highlighting a shared dysregulation in opioid tone between alcohol dependence and other addictions like gambling.
Background And Objective: Amyloid-positron emission tomography (PET) imaging (API) detects amyloid-beta pathology early in the course of Alzheimer's disease (AD) with high sensitivity and specificity. (18)F-florbetapir (Amyvid) is an amyloid-binding PET ligand with a half-life suitable for clinical use outside of the research setting. How API affects patient investigation and management in the 'real-world' arena is unknown.
View Article and Find Full Text PDFObjective: The spleen is more commonly affected in multiorgan disease, but alternative sites are selected for biopsy owing to perceived haemorrhage risk. If these sites are inaccessible or, less commonly, the spleen is the only disease site, then splenic biopsy is considered, with most studies using a 20- to 22-G needle. The primary aim of biopsy is to exclude underlying malignancy or to obtain histological analysis in known malignancy, usually lymphoma, when reclassification is required for therapy.
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