Publications by authors named "Gemma Beard"

Article Synopsis
  • Image-based sexual abuse (IBSA) involves the nonconsensual creation, sharing, or threats related to intimate images, with little research focusing on the perpetrators of these acts.
  • A recent scoping review analyzed 26 studies on the perpetration of IBSA, revealing that those who commit these acts are often young men, and motivations include social rewards and power dynamics.
  • The findings suggest that prevention strategies should target societal attitudes, promote healthy relationships, and build resilience through early interventions.
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Postendocytic sorting of G protein-coupled receptors (GPCRs) is driven by their interactions between highly diverse receptor sequence motifs with their interacting proteins, such as postsynaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), zonula occludens-1 protein (zo-1) (PDZ) domain proteins. However, whether these diverse interactions provide an underlying functional specificity, in addition to driving sorting, is unknown. Here we identify GPCRs that recycle via distinct PDZ ligand/PDZ protein pairs that exploit their recycling machinery primarily for targeted endosomal localization and signaling specificity.

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The laminopathy Hutchinson-Gilford progeria syndrome (HGPS) is caused by the mutant lamin A protein progerin and leads to premature aging of affected children. Despite numerous cell biological and biochemical insights into the basis for the cellular abnormalities seen in HGPS, the mechanism linking progerin to the organismal phenotype is not fully understood. To begin to address the mechanism behind HGPS using Drosophila melanogaster, we have ectopically expressed progerin and lamin A.

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