[Changes in the level of DNA synthesis in a culture of Ehrlich ascites tumor cells under the action of different concentrations of a chalone-containing preparation].

The study was made of the effect of various concentrations of chalone-containing preparation from ascitic Ehrlich tumor on DNA synthesis in the tumor. The preparation was shown to suppress DNA synthesis in dose-dependent manner. The dose dependence was characterized by the effect of saturation which is likely to reflect binding of chalone molecules with specific cell receptors.

[Effects of propranolol on mitosis-inhibiting activity of G2-chalone and adrenaline in cell culture of Ehrlich's ascites tumor].

Chalone-containing preparation from ascite Ehrlich's tumour blocks these cell transition from G2-phase to mitosis and its motion in mitosis in vitro (G2-block, M-block). Adrenaline blocks these cell transition from G2-phase to mitosis. Propranolol raises G2-block of chalone or adrenaline.