Clinical and Laboratory Development of Echinocandin Resistance in : Molecular Characterization.

The pathogenic yeast has become a public health issue due to the increasing number of echinocandin resistant clinical strains reported. In this study, acquisition and development of resistance to this antifungal class were studied in serial isolates from five patients admitted in two Spanish hospitals with a resistant profile against echinocandins associated with different mutations in hot-spot 1 of gene. For two of these patients susceptible wild-type isolates obtained prior to resistant ones were also investigated.