Characterization of Comb-Shaped Copolymers by Multidetection SEC, DLS and SANS.

PolyCarboxylate ether-based superplasticizers (PCEs) are a type of comb-shaped copolymers used as polymeric dispersants in cementitious materials. PCEs have a high degree of dispersity, which limits the suitability of conventional characterization techniques, such as Size Exclusion Chromatography (SEC). Properties of PCEs strongly depend on their molecular structure and a comprehensive characterization is needed to fully understand the structure⁻property relationships.

On the synthesis of α-amino sulfoxides.

A synthetic study on the preparation of N-Boc α-amino sulfoxides has revealed an unexpected instability which is believed to be due to α-elimination of the sulfoxide to give an iminium ion. Full synthetic details are reported on two main synthetic routes: lithiation and sulfinate trapping of N-Boc heterocycles and oxidation of N-Boc α-amino sulfides. Six novel α-amino sulfoxides were successfully prepared and isolated.

Asymmetric lithiation trapping of N-Boc heterocycles at temperatures above -78 °C.

The asymmetric lithiation trapping of N-Boc heterocycles using s-BuLi/chiral diamines at temperatures up to -20 °C is reported. Depending on the N-Boc heterocycle, lithiation is accomplished using s-BuLi and (-)-sparteine or the (+)-sparteine surrogate in the temperature range -50 to -20 °C for short reaction times (2-20 min). Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered functionalized N-Boc heterocycles in 47-95% yield and 77:23-93:7 er.

Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists.

A novel series of 1,2,4-triazol-3-yl-azabicyclo[3.1.0]hexanes with high affinity and selectivity for the DA D(3) receptor and excellent pharmacokinetic profiles was recently reported.

[Characteristics of 86 infants' cluster with A.L.T.E. (Apparent Life-Threatening Event): similarities and differences versus main risk factors for SIDS].

In this study we have gathered 86 ALTE infants' characteristics about physiological, familiar, remote and near pathological case history, modality of apnoea episode's presentation, environmental and behavioural conditions of babies and we have compared these ones with main risk factors for SIDS to find possible similarities or differences. Many of the already known differences or similarities between ALTE and SIDS have been confirmed by our data and new ones have been observed. So we can say that the association between ALTE and SIDS remains contrasting because beside undiscussed factors of association there are other ones which differentiate the two Syndromes.

[Analysis of risk factors for SIDS: experience at a referral center].

The aim of this research is to value, with a questionnary for the families, epidemiologic aspects in 20 children died for SIDS. The risk factors we have considered regard: ambiental condition, pregnancy, neonatal and post-neonatal period, and modality of death. The result is that sleeping position, child's age and month in which the death happens, are still the most significant risk factors for SIDS.

[Cardiorespiratory monitoring in hospital and at home].

Apnoea become a medical problem when associated with a symptomatology cohort characterized by skin colour modifications, muscular tone modifications and consciousness. This syndrome named ALTE, from the acronym Apparent Life Threatening Event, well describes the near death sensation in the witnesses. Only 60% of this events may be revealed in his etiopathogenesis, also even a strong diagnostic protocol is applied; the remaining part, called idiopathic represent a open doubt and stressing factor for the physicians.