Publications by authors named "Geke Zhu"
X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene, leading to the accumulation of very long-chain fatty acids (VLCFAs) in plasma and tissues. It primarily affects the central nervous system white matter and the adrenal cortex. Clinical manifestations include myeloneuropathy, leukodystrophy, and adrenal insufficiency.
View Article and Find Full Text PDFMyasthenia gravis with positive MuSK antibody often involves the bulbar muscles and is usually refractory to acetylcholinesterase inhibitors. For MuSK-MG patients who experience acute exacerbations and do not respond to conventional treatments, there is an urgent need to find more suitable treatment options. With the advent of biologic agents, efgartigimod has shown promising results in the treatment of MG.
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- The analysis assessed the effectiveness and safety of new targeted therapies for generalized myasthenia gravis (gMG) by analyzing data from randomized controlled trials (RCTs).
- A total of 13 studies involving 872 subjects evaluated 10 different drugs, and batoclimab emerged as the most effective treatment, significantly improving patient scores compared to placebo.
- The study utilized complex statistical models to rank the drugs based on efficacy and the risk of adverse events, revealing that while batoclimab showed substantial benefits, other drugs like nipocalimab were less effective.
Hereditary neuropathy with liability to pressure palsy (HNPP) is characterized by acute, painless and recurrent mononeuropathies. Genetic testing shows PMP22 gene deletion of chromosome 17p11.2 can provide evidence for the diagnosis of HNPP.
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