Use of opioids and opioid alternatives during general anesthesia: a pan-Canadian survey among anesthesiologists.

Purpose: While there is limited patient-centred evidence (i.e., evidence that is important for patients and end-users) to inform the use of pharmacologic opioid minimization strategies (i.

Extraction and complexation studies with 2,6-bis(5-(-butyl)-1-pyrazol-3-yl)pyridine in the presence of 2-bromohexanoic acid.

To improve the understanding of the extraction chemistry of An(iii) and Ln(iii) with N-donor ligands 2,6-bis(5-(-butyl)-1-pyrazol-3-yl)pyridine (C4-BPP) in the presence of 2-bromohexanoic acid was investigated. Extraction studies showed an excellent separation factor of SF ≈ 200 and SF ≈ 60 in comparison with the structurally similar ligand 2,6-bis(5-neopentyl-1-pyrazol-3-yl)pyridine C5-BPP (SF ≈ 100), even though C5-BPP showed significantly higher stability constants. Time-resolved laser fluorescence spectroscopy (TRLFS) studies revealed the formation of the ternary 1 : 1 and 1 : 2 complexes [Eu(C4-BPP) (2-bromohexanoate) ] ( = 1-2) ( and ).

Intraoperative pharmacologic opioid minimisation strategies and patient-centred outcomes after surgery: a scoping review.

Background: Postoperative patient-centred outcome measures are essential to capture the patient's experience after surgery. Although a large number of pharmacologic opioid minimisation strategies (i.e.

Effectiveness of dexmedetomidine during surgery under general anaesthesia on patient-centred outcomes: a systematic review and Bayesian meta-analysis protocol.

Introduction: Dexmedetomidine is a promising pharmaceutical strategy to minimise opioid use during surgery. Despite its growing use, it is uncertain whether dexmedetomidine can improve patient-centred outcomes such as quality of recovery and pain.

Methods And Analysis: We will conduct a systematic review and meta-analysis following the recommendations of the .

The effect of remifentanil infusion on sevoflurane minimum alveolar concentration-no movement (MAC) and bispectral index in dogs.

Objective: To determine the effect of remifentanil infusion on the minimum alveolar concentration of sevoflurane preventing movement (SEVOMAC) and bispectral index (BIS) in dogs.

Study Design: Prospective, unmasked study.

Animals: A total of 10 adult Beagle dogs weighing 9.

Insights into the Complexation Mechanism of a Promising Lipophilic PyTri Ligand for Actinide Partitioning from Spent Nuclear Fuel.

The challenging issue of spent nuclear fuel (SNF) management is being tackled by developing advanced technologies that point to reduce environmental footprint, long-term radiotoxicity, volumes and residual heat of the final waste, and to increase the proliferation resistance. The advanced recycling strategy provides several promising processes for a safer reprocessing of SNF. Advanced hydrometallurgical processes can extract minor actinides directly from Plutonium and Uranium Reduction Extraction raffinate by using selective hydrophilic and lipophilic ligands.

Spectroscopic investigation of the covalence of An(III) complexes with tetraethylcarboxamidopyridine.

In this work, we report a combined NMR spectroscopic and time-resolved laser fluorescence spectroscopic (TRLFS) study of the complexation of ,,','-tetraethyl-2,6-carboxamidopyridine (Et-Pic) with Ln(III) (La, Sm, Eu, and Lu), Y(III) and An(III) (Am and Cm). The focal point of this study was the metal-ligand interaction in the [M(Et-Pic)] (M = An and Ln) complexes. The NMR analyses found slight differences between the An(III)-N and Ln(III)-N interactions in contrast to the similar properties of the Am(III)-O and Ln(III)-O interactions.

Intestinal obstruction following gastric bypass.

Purpose: To draw the attention of the medical community to a differential diagnosis of intestinal obstruction due to bezoar in the late postoperative period of gastric bypass that requires diagnosis and emergency management.

Methods: We report 8 cases of patients with intestinal obstruction due to bezoar in the late postoperative period of gastric bypass who required surgical intervention.

Conclusion: Intestinal obstruction due to fruit pomace is a late complication that may require urgent surgical intervention and should be considered in the differential diagnosis.

Internet and social media use in cancer patients: association with distress and perceived benefits and limitations.

Objective: Cancer patients may turn to social media (SM) to cope with distress. We investigated associations between distress and internet/SM use for cancer information/support.

Methods: Adult patients at a Canadian cancer centre completed a cross-sectional survey on sociodemographics, health status, use of cancer online resources and distress (EQ5D-5L).

Impact of Solvent Polarity on the Ligand Configuration in Tetravalent Thorium N-Donor Complexes.

A combined NMR spectroscopic and theoretical study on the complexation of diamagnetic Th(IV) with 2,6-bis(5,6-dipropyl-1,2,4-triazin-3-yl)pyridine (Pr-BTP) was performed. Different ligand configurations were observed for [Th(Pr-BTP)] complexes depending on the solvent's ability to actively form hydrogen bonds. In polar aprotic solvents, a complex is observed, which is isostructural with [M(Pr-BTP)] (M = Am, Ln) complexes studied earlier.

Trivalent Actinide Ions Showing Tenfold Coordination in Solution.

Trivalent actinides generally exhibit ninefold coordination in solution. 2,6-Bis(5,6-dipropyl-1,2,4-triazin-3-yl)pyridine (nPr-BTP), a tridentate nitrogen donor ligand, is known to form ninefold coordinated 1:3 complexes, [An(nPr-BTP)] (An = U, Pu, Am, Cm) in solution. We report a Cm(III) complex with tenfold coordination in solution, [Cm(nPr-BTP)(NO)].

Application Health Monitoring for Extreme-scale Resiliency using Cooperative Fault Management.

Resiliency is and will be a critical factor in determining scientific productivity on current and supercomputers, and beyond. Applications oblivious to and incapable of handling transient soft and hard errors could waste supercomputing resources or, worse, yield misleading scientific insights. We introduce a novel application-driven silent error detection and recovery strategy based on application health monitoring.

Health-related social media use and preferences of adolescent and young adult cancer patients for virtual programming.

Purpose: Adolescents and young adults (AYA) with cancer are increasingly using the internet and social media (SM) for cancer-related information. AYA face specific challenges and thus require tailored resources that meet their needs. We describe the internet and SM preferences of AYA related to their cancer information seeking behaviors and their preferences for a future resource compared to middle-aged adults (MAA).

Activation of the Aromatic Core of 3,3'-(Pyridine-2,6-diylbis(1-1,2,3-triazole-4,1-diyl))bis(propan-1-ol)-Effects on Extraction Performance, Stability Constants, and Basicity.

The "CHON" compatible water-soluble ligand 3,3'-(pyridine-2,6-diylbis(1-1,2,3-triazole-4,1-diyl))bis(propan-1-ol) (PTD) has shown promise for selectively stripping actinide ions from an organic phase containing both actinide and lanthanide ions, by preferential complexation of the former. Aiming at improving its complexation properties, PTD-OMe was synthesized, bearing a methoxy group on the central pyridine ring, thus increasing its basicity and hence complexation strength. Unfortunately, solvent extraction experiments in the range of 0.

Exploring the Subtle Effect of Aliphatic Ring Size on Minor Actinide-Extraction Properties and Metal Ion Speciation in Bis-1,2,4-Triazine Ligands.

The synthesis and evaluation of three novel bis-1,2,4-triazine ligands containing five-membered aliphatic rings are reported. Compared to the more hydrophobic ligands 1-3 containing six-membered aliphatic rings, the distribution ratios for relevant f-block metal ions were approximately one order of magnitude lower in each case. Ligand 10 showed an efficient, selective and rapid separation of Am and Cm from nitric acid.

Learning Environmental Field Exploration with Computationally Constrained Underwater Robots: Gaussian Processes Meet Stochastic Optimal Control.

Autonomous exploration of environmental fields is one of the most promising tasks to be performed by fleets of mobile underwater robots. The goal is to maximize the information gain during the exploration process by integrating an information-metric into the path-planning and control step. Therefore, the system maintains an internal belief representation of the environmental field which incorporates previously collected measurements from the real field.

Contribution of Gd Mössbauer data to the study of the magnetic interaction in heterodinuclear 3d-Gd (3d = Cu, Ni) coordination complexes.

The valence shell of the gadolinium element corresponds to 4f 5d 6s, so that the trivalent Gd ion possesses free 5d and 6s orbitals. It has been previously shown by CASSCF methods that the 5d orbitals, along with the 6s Gd orbitals, which are expected to be unoccupied, present a slight spin density and that the magnetic behaviour of Cu-Gd complexes can only be reproduced if the 5d Gd orbitals are taken into account in the active space. Gd Mössbauer isomer shifts of 3d-Gd complexes, LCuGd(NO), LNiGd(NO)·acetone, LCu(acetone)Gd(NO), LNi(HO)Gd(NO) where L and L are hexadentate Schiff base ligand, are almost unchanged (0.

Time-resolved and steady-state irradiation of hydrophilic sulfonated bis-triazinyl-(bi)pyridines - modelling radiolytic degradation.

Efficient separation of the actinides from the lanthanides is a critical challenge in the development of a more sophisticated spent nuclear fuel recycling process. Based upon the slight differences in f-orbital distribution, a new class of soft nitrogen-donor ligands, the sulfonated bis-triazinyl-(bi)pyridines, has been identified and shown to be successful for this separation under anticipated, large-scale treatment conditions. The radiation robustness of these ligands is key to their implementation; however, current stability studies have yielded conflicting results.