Treatment of glioblastoma in Greenlandic patients.

Glioblastoma (GBM), WHO grade IV, is the most common primary malignant brain tumour among adults with a devastating overall survival of 14-22 months. Standard treatment of GBM includes maximum safe resection, radiotherapy plus concomitant and adjuvant temozolomide (TMZ), given over a period of approximately 9 months. Treatment and follow-up for Greenlandic patients with GBM are managed at Rigshospitalet (RH), Copenhagen.

Helios: History and Anatomy of a Successful In-House Enterprise High-Throughput Screening and Profiling Data Analysis System.

We describe the main characteristics of the Novartis Helios data analysis software system (Novartis, Basel, Switzerland) for plate-based screening and profiling assays, which was designed and built about 11 years ago. It has been in productive use for more than 10 years and is one of the important standard software applications running for a large user community at all Novartis Institutes for BioMedical Research sites globally. A high degree of automation is reached by embedding the data analysis capabilities into a software ecosystem that deals with the management of samples, plates, and result data files, including automated data loading.

[Injuries in male and female adolescent soccer players].

This study addresses the epidemiology of injuries in adolescent male and female soccer players in Germany. Therefore, the purpose of the study was to analyse the injuries in male and female youth soccer players in Germany. This study was designed as a cross-sectional web-based survey.

Modification of Ti6AL4V surfaces using collagen I, III, and fibronectin. II. Influence on osteoblast responses.

Responses of osteoblastic cells are influenced by morphology and composition of the extracellular matrix, and this fact has been used to improve the biological acceptance of implants by modifying the surfaces with components of the extracellular matrix (ECM). In this study, the effect of the collagen types I and III on adhesion, proliferation, and differentiation was studied, using primary osteoblastic cells from rat calvariae. Differences in alkaline phosphatase activity (ALP) and collagen synthesis were observed between differently composed collagen coatings.

Proliferation and differentiation of rat calvarial osteoblasts on type I collagen-coated titanium alloy.

Several attempts have been made to improve osseointegration of titanium alloy as an implant material by modification of its surface. In the present study, proliferation, differentiation, and mineralization of osteoblasts on type I collagen-coated Ti6Al4V were investigated. The activity of alkaline phosphatase and the accumulation of calcium by osteoblasts grown on titanium alloy were significantly higher compared to cells grown on polystyrene.

Collagen type I-coating of Ti6Al4V promotes adhesion of osteoblasts.

The initial contact of osteoblasts with implant surfaces is an important event for osseointegration of implants. Osseointegration of Ti6Al4V may be improved by precoating of its surface with collagen type I. In this study, the adhesion of rat calvarial osteoblasts to uncoated and collagen type I-coated titanium alloy was investigated over a period of 24 h.

Diagnostic and prognostic relevance of malignancy-associated changes in cervical smears.

Objective: For approximately 15 years, malignancy-associated changes (MACs) have been consistently found by means of high-resolution cytometry in different tissues, especially in visually normal appearing cervical cells. Their biologic nature is not yet fully understood. The aim of this investigation was to assess the expression of MACs in cervical smears and to evaluate their prognostic relevance.

Modifications to increase accuracy and consistency of anticoagulant delivery using the Fenwal CS3000 plus.

Consistent and accurate delivery of anticoagulant (AC) with the Fenwal CS3000 Plus has been difficult to maintain. We have modified and evaluated methods to deliver AC more accurately and consistently at a 11:1 ratio on the Fenwal CS 3000 Plus. Two modifications (shortened AC tubing, shortened AC tubing with modified drip chamber) and two unmodified methods (unmodified right-hand string, unmodified double string) were compared (n = 20 platelet apheresis procedures each), resulting in average AC ratios of 11.

[Image analysis study of squamous epithelial cells in cytological smears of the uterine cervix].

The automated image analysis is a method, which may model essential effects of the cytologist's perception, combined with an increase of objectivity. We studied 9136 epithelial cells from 105 suspension smears of the cervix by means of image analysis. The results show that the process of maturation of squamous cells can be represented by image analysis parameters.

[Epidemiology and clinical aspects of adenomatous and squamous epithelial cancers of the uterine cervix].

Compared studies on the epidemiology and clinic of adeno- and squamous-cell carcinoma of the uterine cervix are being carried out by means of a retrospective investigation. 1,481 cervix cancer patients were treated from 1972-1983. Among them were 64 adenocarcinoma patients who were compared with a group of squamous-cell cancer patients equal in number.

[Non-puerperal breast secretion].

This study is a general review about the nonpuerperal secretion of the mammary gland, the cause and the diagnosis. The consequence is unimportant for the diagnosis of carcinoma. About 5 per cent of the breast cancer have pathologic secretion, in most cases a blood-stained one.

[Abdominal metastasis in breast cancer].

Report about three patients which were operated on due to a suspicion of ovarian cancer. In all three cases we could observed metastases of a primary breast cancer. This could be confirmed clinically, mammographically and histologically.

[Morphologic changes in the epithelium of the uterine cervix in long-term administration of the 19-norsteroid-containing oral hormonal contraceptives Non-Ovlon and gravistat].

The objective of this study was to give a contribution to the question whether there are changes in the uterine cervix after longterm application of 19-norsteroid-containing contraceptives Non-Ovlon and Gravistat relating to carcinogenesis. Histologic examinations have been performed on 19,760 cervical sections obtained from 280 women aged 25-45 years. 141 women had taken Non-Ovlon or Gravistat for at least 5 years, 139 women had never taken hormonal contraceptives.

[Peritoneal cytology in the follow-up control of malignant ovarian tumors].

From 1976 to 1982 we practised 247 transvaginal punctures with peritoneal lavage with the aim of cytological follow-up of ovarian malignomas. Those who were submitted to this treatment were 73 women with ovarian carcinoma of stage I to III, in whom after operation, antineoplastic chemotherapy and possibly radiotherapy no tumor was no longer detectable clinically. In case of positive cytology puncture was repeated in intervals of three months, in case of negative findings of 6 to 8 months.

[Bilateral ovarian pregnancy--a rare case of extrauterine pregnancy].

Reported is a case of bilateral intrafollikular ovarian pregnancy. Frequency and genesis were discussed against the background of this case. Reference is made to diagnostic action and therapy of this rare form of ectopic pregnancy.

[Stepped therapy for patients with cervical carcinoma - precancerous and early phases (author's transl)].

Reported in this paper are 806 cases of carcinoma in situ and micro-invasive carcinoma of the uterine cervix (Phases 0 and Ia). All patients had been attended to in the Gynaecological Department of the Medical Academy "Carl Gustav Carus", Dresden, between 1969 and 1978. - The histological diagnosis was based on conisation.

[Malignant melanoma of the vagina].

The authors present the case of a malignant melanoma of the vagina. Simultaneously was noted a pigmented nodule on the left lower eyelid. This tumour was also diagnosed as a malignant melanoma.

[Hemorrhage in menopause and its histological correlation].

In an evaluation of 200 histological endometrial findings of female patients having postmenopausal haemorrhage malign changes were noticed in five per cent of the cases. This figure is much smaller than that which is usually mentioned in literature. However it corresponds in its proportion with the known clinical and anamestic risk factors.